Product image of Lenalidomid Zentiva (Lenalidomide) supplied by GNH India

Lenalidomid Zentiva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Zentiva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Zentiva, is an immunomodulatory drug presented as an oral tablet for oral use. It treats certain blood cancers, notably multiple myeloma and myelodysplastic syndromes with del(5q), in adult patients. GNH India supplies Lenalidomid Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Zentiva Pharma Gmbh

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Indications & Clinical Uses

Lenalidomid Zentiva is indicated for hematologic malignancies that respond to immunomodulation.

  • Multiple Myeloma: used as part of combination therapy to control disease progression in adult patients.
  • Myelodysplastic Syndromes with del(5q): improves blood counts and reduces transfusion dependence in adult patients.
  • Relapsed/Refractory Multiple Myeloma: employed after prior therapies to achieve disease control.

How It Works

  • Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to degradation of transcription factors Ikaros and Aiolos, resulting in reduced proliferation of malignant plasma cells, inhibition of angiogenesis, and modulation of cytokine production that enhances immune‑mediated tumor cell killing.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels that may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require supportive care.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe cutaneous reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers unrelated to the original disease.

Precautions & Warnings

Lenalidomid Zentiva requires careful monitoring and specific safety measures.

  • Pregnancy contraindication: drug is Category X and must not be used during pregnancy.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation when appropriate.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Infection vigilance: monitor for signs of infection and manage promptly.
  • Drug interaction awareness: avoid concomitant use with strong CYP3A4 inhibitors.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomid Zentiva can interact with several medicines, requiring clinical attention.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lenalidomide exposure.
  • Thalidomide: combined use adds teratogenic risk.
  • Pregnancy: drug is contraindicated and must be avoided.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce drug effectiveness.
  • Anticoagulants: may enhance bleeding tendency.
  • Live vaccines: immune response may be diminished, requiring caution.

Frequently Asked Questions

Lenalidomid Zentiva is prescribed for adult patients with multiple myeloma and for those with myelodysplastic syndromes that have the del(5q) chromosomal abnormality. In both settings, it is used to control disease progression, improve blood counts, and reduce the need for transfusions as part of a broader treatment plan.

Lenalidomide binds to the cereblon protein within the CRL4‑CRBN ubiquitin‑ligase complex, altering its activity. This triggers degradation of specific transcription factors, leading to reduced proliferation of malignant cells, inhibition of new blood‑vessel formation, and modulation of immune responses that help the body target cancer cells.

The exact dose of Lenalidomid Zentiva is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and other individual factors. Healthcare professionals follow approved dosing guidelines and adjust the regimen as needed for safety and efficacy.

Lenalidomid Zentiva is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. Women of childbearing potential must use effective contraception, and the drug should not be used while breastfeeding because it may pass into breast milk.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lenalidomid Zentiva belongs to the immunomodulatory drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, which can be more convenient, and has demonstrated efficacy in combination regimens, though safety profiles and specific patient suitability differ among therapies.

Lenalidomid Zentiva should be stored at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Lenalidomid Zentiva is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should follow the dosing schedule provided by their healthcare professional and should not alter the dose or frequency without medical advice.

The most serious risks include venous thromboembolism, severe cutaneous reactions such as Stevens‑Johnson syndrome, secondary primary malignancies, and profound hematologic toxicities like neutropenia and thrombocytopenia. Prompt medical attention is required if any signs of these conditions appear.

Lenalidomid Zentiva should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled infections or severe hepatic impairment unless specifically advised by a specialist. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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