Product image of Lenalidomid Zentiva (Lenalidomide) supplied by GNH India

Lenalidomid Zentiva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Zentiva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Zentiva, is an immunomodulatory drug presented as an oral tablet for oral administration. It is indicated for the treatment of adult patients with multiple myeloma and for certain myelodysplastic syndromes, where it helps control disease progression and related complications.

GNH India supplies Lenalidomid Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. All batches are consistently manufactured under EU Good Manufacturing Practice and meet stringent quality standards.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies and related bone marrow disorders.
  • Multiple myeloma: reduces tumor burden and prolongs progression‑free survival in adult patients.
  • Myelodysplastic syndromes with del(5q): improves blood counts and reduces transfusion dependence.
  • Multiple myeloma (maintenance): helps maintain remission after autologous stem cell transplantation.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which modulates cytokine production, inhibits angiogenesis, and suppresses malignant plasma cell proliferation. The resulting anti‑inflammatory, anti‑angiogenic and anti‑proliferative actions underlie its therapeutic effect in hematologic cancers in patients with disease.

Side Effects

Lenalidomid Zentiva may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Neutropenia: reduced white blood cell count.
  • Thrombocytopenia: lowered platelet levels.
  • Fatigue: persistent tiredness.
  • Nausea: feeling of sickness.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in veins.
  • Severe neutropenia or thrombocytopenia: risk of infection or bleeding.
  • Secondary primary malignancies: emergence of new cancers.
  • Hypersensitivity reactions: rash, fever, or anaphylaxis.

Precautions & Warnings

  • Before prescribing Lenalidomid Zentiva, clinicians should consider several safety measures.
  • Pregnancy: contraindicated; drug is teratogenic (Category X).
  • Thrombosis risk: assess patient history and consider prophylaxis.
  • Renal impairment: adjust dose based on renal function.
  • Hematologic monitoring: perform regular CBC to detect cytopenias.
  • Drug interactions: avoid concomitant use with strong CYP inducers.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomid Zentiva interacts with several medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may markedly reduce lenalidomide exposure.
  • Anticoagulants (warfarin): increased risk of thrombosis.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (aspirin): additive bleeding risk.
  • CYP3A4 inhibitors (ketoconazole): may increase lenalidomide plasma levels.
  • Immunosuppressants (cyclosporine): potential for enhanced toxicity.

Frequently Asked Questions

Lenalidomid Zentiva contains lenalidomide, an immunomodulatory agent approved for the treatment of adult patients with multiple myeloma and for certain myelodysplastic syndromes, particularly those with a del(5q) chromosomal abnormality.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, causing selective degradation of transcription factors Ikaros and Aiolos. This disrupts cytokine signaling, inhibits angiogenesis, and suppresses proliferation of malignant plasma cells, producing anti‑cancer effects.

The dosage of Lenalidomid Zentiva is individualized by the prescribing clinician based on the specific indication, disease stage, renal function, and patient tolerance. Only a qualified healthcare professional should determine the appropriate regimen.

Lenalidomid Zentiva is classified as Pregnancy Category X because it is teratogenic and can cause fetal harm. It should not be used during pregnancy, and breastfeeding is contraindicated due to the risk of drug exposure to the infant.

To request Lenalidomid Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative within the same class is thalidomide, while pomalidomide is a newer analogue. Lenalidomide generally offers a more favorable safety profile than thalidomide, with lower rates of peripheral neuropathy, and provides stronger anti‑angiogenic activity compared with pomalidomide in certain settings.

Lenalidomid Zentiva should be stored at ambient temperature below 25 °C, in the original packaging, protected from moisture and light. Keep the product out of reach of children and do not use after the expiration date printed on the label.

The medication is supplied as oral tablets that are swallowed whole with water. It may be taken with or without food, but consistency with respect to meals is recommended to maintain stable absorption.

Serious adverse events include venous thromboembolism, severe neutropenia or thrombocytopenia leading to infection or bleeding, secondary primary malignancies, and hypersensitivity reactions such as rash or anaphylaxis. Patients should be monitored closely for these conditions.

Lenalidomid Zentiva is contraindicated in pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with severe renal impairment unless dose adjustments are made. Caution is also advised for those with a history of thromboembolic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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