Product image of Lenalidomida Olainfarm (Lenalidomide) supplied by GNH India

Lenalidomida Olainfarm

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Olainfarm (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Olainfarm, is an immunomodulatory drug (IMiD) presented as an oral formulation for systemic use. It is employed in the treatment of certain hematologic malignancies, notably multiple myeloma and myelodysplastic syndromes with a 5q chromosomal deletion, in adult patients.

GNH India supplies Lenalidomida Olainfarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The product complies with EU quality standards and is manufactured under GMP conditions. It is distributed through a secure, temperature‑controlled logistics network.

Manufacturer / TM Owner

Jsc Olainfarm

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Indications & Clinical Uses

Lenalidomide is employed in hematologic oncology to modulate the immune environment, inhibit angiogenesis, and promote apoptosis of malignant cells, particularly in plasma‑cell and myeloid disorders.

  • Multiple myeloma: improves progression‑free survival and overall response rates in adult patients.
  • Myelodysplastic syndromes with 5q deletion: induces transfusion independence and cytogenetic remission in affected individuals.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity and leading to ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). This results in reduced survival signals for malignant cells, modulation of cytokine production, inhibition of angiogenesis, and enhanced immune‑mediated tumor cell clearance. Additionally, it influences the tumor microenvironment by decreasing pro‑inflammatory mediators and enhancing natural killer cell activity.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Neutropenia: decreased neutrophil count, increasing infection risk.
  • Thrombocytopenia: reduced platelet levels, may cause bruising or bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: loose stools that may lead to dehydration.
  • Rash: skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism, potentially life‑threatening.
  • Severe neutropenia: profound drop in neutrophils leading to febrile infections.
  • Secondary primary malignancies: emergence of new cancers during therapy.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

When prescribing Lenalidomide, clinicians should observe several safety considerations to minimize risks.

  • Pregnancy contraindication: drug is teratogenic (Category X) and must not be used during pregnancy.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation.
  • Hematologic monitoring: perform regular complete blood counts to detect neutropenia or thrombocytopenia.
  • Renal and hepatic impairment: adjust dose or monitor closely in patients with organ dysfunction.
  • Contraception requirement: both male and female patients of reproductive potential must use effective contraception during treatment and for a defined period after discontinuation.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Lenalidomide interacts with several medicines; awareness of major and moderate interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Thalidomide co‑administration: combined teratogenic risk and overlapping toxicities.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly reduce lenalidomide exposure.
  • Anticoagulants (warfarin, direct oral anticoagulants): increase risk of severe thrombosis or bleeding.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma levels modestly.
  • Live vaccines: reduced efficacy and potential infection risk while on therapy.

Frequently Asked Questions

Lenalidomida Olainfarm, containing the active ingredient lenalidomide, is indicated for adult patients with multiple myeloma and for those with myelodysplastic syndromes that carry a deletion of the 5q chromosome. In these settings, the drug helps control disease progression, improve blood counts, and reduce the need for transfusions.

Lenalidomide binds to the cereblon component of an E3 ubiquitin ligase complex, changing the complex’s target proteins. This leads to the degradation of transcription factors Ikaros and Aiolos, which are important for the survival of malignant cells. The result is reduced tumor growth, altered cytokine production, inhibition of new blood‑vessel formation, and enhanced immune‑mediated killing of cancer cells.

The specific dose of Lenalidomida Olainfarm is set by the prescribing clinician based on the approved indication, the patient’s overall health, renal and hepatic function, and any concomitant medications. Because dosing can vary widely, patients should follow the exact regimen written on their prescription and not adjust the amount on their own.

Lenalidomida Olainfarm is classified as Pregnancy Category X, meaning it is known to cause fetal harm and is contraindicated in pregnancy. Women of child‑bearing potential must use effective contraception before, during, and after treatment. The drug is also not recommended while breastfeeding because it may pass into breast milk and affect the infant.

To request Lenalidomida Olainfarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled logistics), and the necessary import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory drug class, but lenalidomide generally offers a more favorable safety profile, especially regarding peripheral neuropathy. Lenalidomide also has stronger anti‑angiogenic and anti‑proliferative effects, making it the preferred option for many patients with multiple myeloma or 5q‑deleted myelodysplastic syndromes, while thalidomide may still be used in specific circumstances.

Lenalidomida Olainfarm should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture and light. Do not store in areas where temperature may exceed the recommended range, and keep it out of reach of children.

Lenalidomida Olainfarm is taken orally, usually as a whole tablet swallowed with water. It may be taken with or without food, depending on the prescriber’s instructions. Patients should not crush, split, or chew the tablet unless specifically advised, and they should follow the dosing schedule provided by their healthcare professional.

The most serious risks include the potential for venous thromboembolism (blood clots), severe neutropenia that can lead to life‑threatening infections, secondary primary malignancies, and significant liver toxicity. Patients should be monitored closely for signs of these events, and any concerning symptoms should be reported to a healthcare provider immediately.

Lenalidomida Olainfarm should not be used by pregnant women, individuals with uncontrolled infections, or patients with severe renal or hepatic impairment without dose adjustment. It is also contraindicated in patients who cannot adhere to strict contraception requirements or who have a known hypersensitivity to lenalidomide or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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