Product image of Lenalidomida Olainfarm (Lenalidomide) supplied by GNH India

Lenalidomida Olainfarm

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Olainfarm (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Olainfarm, is an immunomodulatory agent presented as an oral tablet for systemic use. It is indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes bearing a del(5q) abnormality, and mantle cell lymphoma, providing anti‑proliferative and anti‑angiogenic effects. The drug’s mechanism involves binding to cereblon, leading to degradation of transcription factors that drive malignant cell growth.

GNH India supplies Lenalidomida Olainfarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide, ensuring quality, regulatory conformity, and reliable logistics for global distribution.

Manufacturer / TM Owner

Jsc Olainfarm

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies and related blood disorders.
  • Multiple Myeloma: improves disease control and prolongs survival in adult patients with relapsed or refractory disease.
  • Myelodysplastic Syndromes: reduces transfusion dependence and improves blood counts in patients with del(5q) cytogenetic abnormality.
  • Mantle Cell Lymphoma: provides disease control in adult patients with relapsed or refractory mantle cell lymphoma.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This interaction promotes ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), leading to reduced proliferation, increased apoptosis, and inhibition of angiogenesis in malignant plasma cells and other hematologic cancer cells. The drug also modulates cytokine production within the tumor microenvironment, further contributing to its antineoplastic activity.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Neutropenia: decreased neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels that may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may lead to dehydration.
  • Nausea: upset stomach often occurring after dosing.
  • Rash: skin irritation or mild eruptions.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatic failure: significant liver enzyme elevation or dysfunction.
  • Severe infections: opportunistic or life‑threatening bacterial, viral, or fungal infections.
  • Tumor lysis syndrome: rapid tumor cell breakdown causing metabolic disturbances.

Precautions & Warnings

  • Before initiating Lenalidomida Olainfarm, clinicians should consider several safety measures.
  • Pregnancy: contraindicated due to teratogenic risk; ensure effective contraception.
  • Breastfeeding: not recommended; advise discontinuation of nursing.
  • Monitor blood counts: perform regular CBC to detect neutropenia or thrombocytopenia.
  • Assess thrombotic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Adjust dose in renal impairment: evaluate renal function and modify dosing accordingly.
  • Store at ambient temperature: keep below 25°C, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomide can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase lenalidomide exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin): may reduce therapeutic levels.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • P‑gp inhibitors (e.g., verapamil): may modestly raise plasma concentrations.
  • NSAIDs: may add to thrombotic risk when combined with lenalidomide.

Frequently Asked Questions

Lenalidomida Olainfarm contains lenalidomide, an immunomodulatory antineoplastic indicated for adult patients with multiple myeloma, myelodysplastic syndromes that have a del(5q) chromosomal abnormality, and mantle cell lymphoma. It is prescribed to control disease progression, improve blood counts, and extend survival in these hematologic cancers.

Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, changing its substrate profile. This leads to the ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, which reduces malignant cell proliferation, induces apoptosis, and blocks angiogenesis, thereby exerting antitumor activity.

The specific dose of Lenalidomida Olainfarm is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and other individual factors. No universal dosing regimen is provided here; the prescriber will set the appropriate regimen and any necessary adjustments.

Lenalidomida Olainfarm is classified as Pregnancy Category X because it is teratogenic and can cause fetal harm. It is contraindicated in pregnant women and should not be used during pregnancy. Breastfeeding is also not recommended, as the drug may be excreted in milk and affect the infant.

To request Lenalidomida Olainfarm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Lenalidomide is a second‑generation immunomodulatory drug, offering a more favorable safety profile than thalidomide, especially regarding peripheral neuropathy. Compared with pomalidomide, another newer agent, lenalidomide is often used earlier in treatment lines and has a broader indication set, though pomalidomide may be preferred in certain refractory cases.

Lenalidomida Olainfarm should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in areas with high humidity or direct sunlight.

The medication is supplied as oral tablets that should be swallowed whole with water. It can be taken with or without food, according to the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

Serious risks include venous thromboembolism (blood clots), severe neutropenia or thrombocytopenia that can lead to infections or bleeding, secondary primary malignancies, and hepatic toxicity. Patients should be monitored regularly for signs of these events, and any sudden symptoms should be reported to a healthcare provider immediately.

Lenalidomida Olainfarm should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or any excipients, patients with uncontrolled infections, or those with severe renal impairment without dose adjustment. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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