Product image of Lenalidomida Qilu (Lenalidomide) supplied by GNH India

Lenalidomida Qilu

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Qilu (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Qilu, is an immunomodulatory agent (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma, in adult patients under specialist supervision.

GNH India supplies Lenalidomida Qilu as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Qilu Pharma Spain S.L.

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Indications & Clinical Uses

Lenalidomida Qilu is an immunomodulatory antineoplastic that targets malignant plasma cells and dysplastic hematopoietic clones. It is employed in the following approved indications:

  • Multiple myeloma: improves progression‑free survival and overall response rates when used in combination regimens.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and induces cytogenetic remission.
  • Mantle cell lymphoma: contributes to disease control as part of combination therapy.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors such as Ikaros and Aiolos, resulting in immunomodulation, anti‑angiogenic activity, and direct anti‑tumor effects in malignant cells.

Side Effects

Lenalidomida Qilu may cause a range of adverse reactions. Patients should be monitored regularly for both common and serious events.

Common Side Effects

  • Neutropenia: reduced neutrophil count, increasing infection risk.
  • Thrombocytopenia: lowered platelet levels, may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: upset stomach, sometimes with vomiting.
  • Diarrhea: loose stools, may lead to dehydration.
  • Rash: skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly low neutrophils requiring hospitalization.
  • Severe thrombocytopenia: dangerous bleeding events.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatotoxicity: significant liver enzyme elevation.
  • Anaphylaxis: rare severe allergic reaction.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline parameters and educate patients on safety measures.

  • Blood count monitoring: perform complete blood counts weekly during the first two cycles.
  • Thromboembolic risk assessment: consider prophylactic anticoagulation in high‑risk patients.
  • Pregnancy avoidance: enforce strict contraception; drug is teratogenic.
  • Renal function adjustment: dose may need modification in moderate to severe renal impairment.
  • Store below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomida Qilu can interact with several medicines; awareness helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly lower lenalidomide exposure.
  • Concurrent use with other immunomodulatory agents: may amplify hematologic toxicity.
  • Anticoagulants combined with high thrombotic risk: heightened chance of clot formation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): modestly increase drug levels.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can worsen renal function.
  • Live vaccines: reduced efficacy; avoid during treatment.

Frequently Asked Questions

Lenalidomida Qilu is prescribed for adult patients with certain hematologic cancers. It is approved to treat multiple myeloma, myelodysplastic syndromes that carry a del(5q) chromosome abnormality, and mantle cell lymphoma, typically as part of combination chemotherapy protocols.

Lenalidomide binds to cereblon, a component of the CRL4CRBN E3 ubiquitin ligase complex. This binding changes the complex’s substrate preference, leading to the degradation of transcription factors such as Ikaros and Aiolos. The result is immunomodulation, inhibition of new blood‑vessel formation, and direct anti‑tumor activity against malignant cells.

The specific dose of Lenalidomida Qilu is individualized by the treating physician based on the patient’s diagnosis, disease stage, renal function, and concurrent therapies. Only a qualified healthcare professional should determine the appropriate dosing schedule.

Lenalidomida Qilu is classified as Pregnancy Category X, meaning it is known to cause fetal harm and is contraindicated during pregnancy. Women of childbearing potential must use effective contraception. The drug is also not recommended while breastfeeding because it may pass into breast milk and affect the infant.

To request Lenalidomida Qilu, visit the product page on gnhindia.com, enter the desired quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

The primary alternative to lenalidomide is thalidomide, another immunomodulatory agent, and pomalidomide, a newer IMiD. Lenalidomide generally offers a more favorable safety profile than thalidomide, especially regarding peripheral neuropathy, while providing comparable anti‑myeloma efficacy. Compared with pomalidomide, lenalidomide is often used earlier in treatment sequences and has a broader indication set.

Lenalidomida Qilu should be stored at or below 25 °C (77 °F) in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat. Do not store in the bathroom or near a kitchen sink. Ensure the container is tightly closed when not in use.

Lenalidomida Qilu is taken orally, usually once daily, with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water. Patients should follow the exact schedule provided by their healthcare professional and not alter the dosing interval without medical advice.

The most critical risks include severe neutropenia and thrombocytopenia, which can lead to life‑threatening infections or bleeding, and venous thromboembolism such as deep‑vein thrombosis or pulmonary embolism. Secondary primary malignancies have also been reported. Patients should promptly report fever, unusual bruising, shortness of breath, or sudden leg pain.

Lenalidomida Qilu is contraindicated in pregnant women and in individuals with known hypersensitivity to lenalidomide or any excipients in the tablet. Caution is advised for patients with severe renal impairment, uncontrolled infections, or a history of thromboembolic events unless appropriate prophylaxis is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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