Product image of Lenalidomida Stada (Lenalidomide) supplied by GNH India

Lenalidomida Stada

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Stada (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Stada, is an immunomodulatory agent (IMiD) presented as an oral tablet for systemic use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomida Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide with reliable logistics.

Manufacturer / TM Owner

Stada Lda.

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies and related disorders, targeting abnormal plasma cells and dysplastic clones.

  • Multiple Myeloma: improves progression‑free survival and overall response rates in adult patients.
  • Myelodysplastic Syndromes with del(5q): reduces transfusion dependence and induces cytogenetic remission.
  • Mantle Cell Lymphoma: provides disease control in relapsed or refractory cases.

How It Works

  • Lenalidomide binds the cereblon component of the CRL4‑E3 ubiquitin ligase complex, leading to selective degradation of the transcription factors Ikaros and Aiolos. This results in anti‑angiogenic, anti‑inflammatory, and immunomodulatory actions that inhibit tumor cell proliferation and restore immune surveillance.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require fluid replacement.
  • Rash: skin redness or itching.
  • Nausea: feeling of sickness that may lead to vomiting.

Serious or Rare Side Effects

  • Thromboembolic events: blood clots such as deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly reduced neutrophil count increasing infection risk.
  • Secondary primary malignancies: emergence of new cancers unrelated to the original disease.

Precautions & Warnings

When prescribing Lenalidomida Stada, clinicians should consider several safety and handling precautions.

  • Pregnancy risk: avoid use in pregnant women; a risk management program is required.
  • Thrombosis prophylaxis: assess need for anticoagulation in patients with additional risk factors.
  • Renal impairment: adjust monitoring in patients with reduced kidney function.
  • Hepatic impairment: monitor liver function tests regularly.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may lower lenalidomide exposure (e.g., rifampin, carbamazepine).
  • Anticoagulants: increased risk of bleeding when combined with warfarin or direct oral anticoagulants.
  • Immunosuppressants: may enhance immunosuppression, raising infection risk.

Moderate Interactions (Monitor Closely)

  • P-glycoprotein inhibitors: may increase plasma levels (e.g., verapamil, quinidine).
  • NSAIDs: can exacerbate renal toxicity.
  • Vaccines: live attenuated vaccines may be less effective; avoid during therapy.

Frequently Asked Questions

Lenalidomida Stada contains lenalidomide, an immunomodulatory drug approved for adult patients with multiple myeloma, myelodysplastic syndromes that have a del(5q) chromosomal abnormality, and mantle cell lymphoma, particularly in relapsed or refractory settings.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, triggering degradation of transcription factors Ikaros and Aiolos. This leads to anti‑angiogenic, anti‑inflammatory, and immunomodulatory effects that suppress malignant cell growth and enhance immune‑mediated tumor clearance.

The specific dose of Lenalidomida Stada is determined by the treating physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Prescribers follow approved dosing guidelines and adjust as needed.

Lenalidomida Stada is contraindicated in pregnancy because it can cause fetal harm. Women of childbearing potential must use effective contraception. Safety during breastfeeding has not been established, so nursing is generally discouraged while on therapy.

To order Lenalidomida Stada, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both lenalidomide and thalidomide belong to the same immunomodulatory class, but lenalidomide is more potent, has a better safety profile, and is approved for a broader range of hematologic cancers. Thalidomide is associated with higher rates of peripheral neuropathy and sedation, whereas lenalidomide shows fewer neurotoxic effects.

Lenalidomida Stada should be stored at ambient temperature, preferably below 25 °C, in the original blister or bottle. Keep the product away from moisture, direct sunlight, and excessive heat. Do not refrigerate or freeze the tablets.

Lenalidomida Stada is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets are swallowed whole with a glass of water. Patients should follow the dosing schedule provided by their healthcare professional.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe neutropenia that can predispose to infections, and the possible development of secondary primary malignancies. Patients should be monitored regularly for signs of clotting, infection, and new cancer diagnoses.

Lenalidomida Stada should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled active infections. Caution is also advised in those with severe renal or hepatic impairment, where dose adjustments may be required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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