Product image of Lenalidomida Teva (Lenalidomide) supplied by GNH India

Lenalidomida Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Teva, is a Immunomodulatory drug (IMiD) presented as an oral formulation for oral use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes with the del(5q) chromosome abnormality.

GNH India supplies Lenalidomida Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Lenalidomida Teva is an immunomodulatory agent used in specific hematologic malignancies.
  • Multiple myeloma: improves disease control and prolongs survival in patients with relapsed or refractory disease.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and can lead to cytogenetic remission.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4CRBN E3 ubiquitin ligase complex, altering substrate specificity. This results in the ubiquitination and degradation of transcription factors Ikaros and Aiolos, leading to immunomodulatory, anti‑angiogenic, and direct anti‑tumor effects that inhibit malignant plasma cell proliferation.

Side Effects

Lenalidomida Teva may cause a range of adverse reactions.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels causing bleeding tendencies.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may lead to dehydration.
  • Rash: skin irritation or erythema.
  • Nausea: feeling of sickness often accompanied by vomiting.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary malignancies: emergence of new cancers.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Embryo‑fetal toxicity: severe birth defects if exposure occurs during pregnancy.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient risk factors and monitor laboratory parameters.
  • Pregnancy contraindication: avoid use in pregnant women; teratogenic risk is category X.
  • Thromboembolic risk: assess need for prophylactic anticoagulation.
  • Renal impairment: adjust monitoring for patients with reduced kidney function.
  • Hematologic monitoring: regular CBC to detect neutropenia or thrombocytopenia.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomida Teva can interact with several concomitant medications.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce drug exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • P-glycoprotein inhibitors: may elevate plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase exposure.
  • Immunosuppressants (e.g., cyclosporine): potential additive hematologic toxicity.
  • Vaccines: live attenuated vaccines should be avoided during treatment.

Frequently Asked Questions

Lenalidomida Teva is prescribed for patients with multiple myeloma, particularly in relapsed or refractory settings, and for those with myelodysplastic syndromes that carry the del(5q) chromosomal abnormality. In both cases, the drug helps control disease progression and can reduce the need for blood transfusions.

Lenalidomide binds to the cereblon protein within the CRL4CRBN E3 ubiquitin ligase complex, changing its substrate specificity. This triggers the degradation of transcription factors Ikaros and Aiolos, leading to enhanced immune cell activity, inhibition of new blood vessel formation, and direct anti‑tumor effects that suppress malignant plasma cells.

The specific dose and schedule of Lenalidomida Teva are determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Healthcare providers tailor the regimen to achieve optimal therapeutic benefit while minimizing risk.

Lenalidomida Teva is classified as pregnancy category X because it can cause severe fetal harm, including birth defects. It is contraindicated in pregnant women and should not be used by women who are breastfeeding, as the drug may be excreted in breast milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lenalidomida Teva belongs to the immunomodulatory drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, which can be more convenient, and has demonstrated efficacy in relapsed or refractory multiple myeloma, often used in combination regimens to enhance response rates.

Lenalidomida Teva should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lenalidomida Teva is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets are swallowed whole with a glass of water, and the dosing schedule (e.g., daily or on specific days of a cycle) is individualized for each patient.

The most serious risks include severe neutropenia and thrombocytopenia, which can lead to infections or bleeding, as well as venous thromboembolism, embryo‑fetal toxicity, and rare but severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for these events throughout therapy.

Lenalidomida Teva is contraindicated in pregnant women and in individuals with known hypersensitivity to lenalidomide or any component of the formulation. Caution is also advised for patients with severe renal impairment, uncontrolled infections, or a history of thromboembolic events unless appropriate prophylaxis is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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