Product image of Lenalidomida Teva (Lenalidomide) supplied by GNH India

Lenalidomida Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomida Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomida Teva, is an immunomodulatory drug presented as an oral formulation for oral use. It treats multiple myeloma and myelodysplastic syndromes with 5q deletion in adult patients.

GNH India supplies Lenalidomida Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Lenalidomide is an immunomodulatory antineoplastic that targets malignant plasma cells and dysplastic hematopoietic clones.
  • Multiple Myeloma: improves response rates and prolongs progression‑free survival in eligible adults.
  • Myelodysplastic Syndromes with 5q deletion: reduces transfusion dependence and induces cytogenetic remission.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, altering substrate specificity. This leads to degradation of transcription factors Ikaros and Aiolos, resulting in reduced proliferation of malignant cells, enhanced immune‑mediated tumor cell clearance, and inhibition of angiogenesis.

Side Effects

Lenalidomide may cause a range of adverse reactions.

Common Side Effects

  • Neutropenia: decreased neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels that may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: mild to moderate gastrointestinal upset.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers during therapy.

Precautions & Warnings

  • Before initiating therapy, clinicians should assess baseline laboratory values and risk factors.
  • Monitor blood counts: perform regular CBCs to detect cytopenias.
  • Assess thromboembolic risk: consider prophylactic anticoagulation when indicated.
  • Evaluate renal and hepatic function: adjust therapy if impairment is present.
  • Avoid in pregnancy: teratogenic potential requires strict contraception.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture.

Avoid Interactions

Lenalidomide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce therapeutic exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: heightened risk of infection due to immunomodulation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • NSAIDs: additive effect on platelet inhibition.
  • Immunosuppressants (e.g., cyclosporine): may enhance hematologic toxicity.

Frequently Asked Questions

Lenalidomida Teva contains lenalidomide, which is approved for the treatment of multiple myeloma and myelodysplastic syndromes that carry a deletion of the 5q chromosome region. In these diseases it helps control malignant cell growth and improves blood counts.

Lenalidomide binds to the cereblon protein within the CRL4 E3 ubiquitin ligase complex. This binding changes the complex’s target proteins, leading to degradation of transcription factors that support cancer cell survival, while also enhancing immune‑mediated tumor cell killing and inhibiting new blood‑vessel formation.

The specific dose and schedule of Lenalidomida Teva are determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Only a qualified healthcare professional should set the dosing regimen.

Lenalidomide is classified as potentially teratogenic, and its safety in pregnancy has not been established. Women of childbearing potential must use effective contraception, and the drug should be avoided during pregnancy and breastfeeding unless the benefits clearly outweigh the risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism from proteasome inhibitors or monoclonal antibodies. It is often used in combination regimens and provides oral administration, which can be more convenient than injectable alternatives, while delivering comparable efficacy in many clinical settings.

Lenalidomida Teva should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and store it out of direct sunlight to maintain stability.

The medication is taken orally, usually with a glass of water. It may be prescribed with or without food depending on the physician’s instructions. Patients should follow the dosing schedule provided by their healthcare provider and not alter the regimen without medical advice.

Serious risks include venous thromboembolism, severe skin reactions such as Stevens‑Johnson syndrome, secondary primary malignancies, and profound cytopenias that can lead to infection or bleeding. Patients should be monitored closely for these events and report any concerning symptoms promptly.

Lenalidomida Teva is contraindicated in patients with known hypersensitivity to lenalidomide or any component of the formulation, in pregnant women, and in individuals with severe uncontrolled infections or uncontrolled thrombotic disorders unless appropriate prophylaxis is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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