Product image of Lenalidomidă Dr. Reddy’s (Lenalidomide) supplied by GNH India

Lenalidomidă Dr. Reddy’s

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomidă Dr. Reddy’s (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomidă Dr. Reddy’s, is an immunomodulatory imide drug (IMiD) presented as an oral formulation for oral use. It is employed in the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma, in adult patients.

GNH India supplies Lenalidomidă Dr. Reddy’s as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies, clinics and procurement teams worldwide, with EU‑GMP‑certified manufacturing and full regulatory documentation.

Manufacturer / TM Owner

Dr. Reddy's Laboratories Romania S.R.L.

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies and related disorders, targeting abnormal plasma cells and dysplastic bone‑marrow clones.

  • Multiple myeloma: improves progression‑free survival and overall response rates in adult patients.
  • Myelodysplastic syndromes (MDS): reduces transfusion dependence and delays transformation to acute leukemia.
  • Mantle cell lymphoma: enhances response when combined with other agents in relapsed or refractory disease.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity and promoting degradation of transcription factors such as Ikaros and Aiolos. This modulates cytokine production, inhibits angiogenesis, and induces apoptosis in malignant cells, thereby restoring immune surveillance and reducing tumor growth.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue
  • Diarrhea
  • Rash
  • Low blood counts (neutropenia, anemia)

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Severe neutropenia leading to infection
  • Secondary primary malignancies

Precautions & Warnings

Before initiating therapy, clinicians should evaluate several safety considerations.

  • Pregnancy: contraindicated; use effective contraception and confirm negative pregnancy test before initiating therapy.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation when risk factors are present.
  • Hematologic monitoring: perform regular complete blood counts to detect neutropenia, anemia or thrombocytopenia.
  • Renal impairment: adjust dosing and monitor renal function in patients with reduced clearance.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine) – may markedly reduce exposure.
  • Anticoagulants (warfarin) – increased risk of bleeding; requires close INR monitoring.
  • Immunosuppressants (e.g., cyclosporine) – may enhance toxicity.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole) – may increase plasma levels.
  • P‑glycoprotein substrates (e.g., digoxin) – potential for altered concentrations.
  • Live attenuated vaccines – risk of reduced efficacy or infection.

Frequently Asked Questions

Lenalidomidă Dr. Reddy’s contains lenalidomide, which is indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes (including those with del(5q) cytogenetic abnormality), and mantle cell lymphoma, typically as part of combination therapy in relapsed or refractory settings.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, altering the degradation of specific transcription factors. This leads to reduced cytokine production, inhibition of new blood‑vessel formation, and promotion of programmed cell death in malignant cells, thereby enhancing immune‑mediated tumor control.

The dose of lenalidomide is individualized by the prescribing clinician based on the specific indication, disease stage, renal function, and patient tolerance. Dosage regimens are detailed in the product labeling and must be followed exactly as directed by a qualified healthcare professional.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because of a high risk of fetal harm. Women of child‑bearing potential must use effective contraception. The drug is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory imide drug (IMiD) class, but lenalidomide is more potent, has a shorter half‑life, and generally exhibits a more favorable safety profile, especially regarding peripheral neuropathy. Clinical studies often favor lenalidomide for multiple myeloma and certain MDS subtypes due to higher response rates.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not refrigerate or freeze the tablets, and discard any product that shows signs of damage or discoloration.

Lenalidomidă Dr. Reddy’s is taken orally, usually once daily, with or without food, as directed by the treating physician. Swallow the tablet whole with a glass of water; do not crush, split, or chew unless the prescribing information specifically allows it.

The most serious risks include deep vein thrombosis or pulmonary embolism, severe neutropenia that can lead to life‑threatening infections, and the potential development of secondary primary malignancies. Patients should be monitored closely for signs of clotting, infection, and any new cancerous lesions throughout therapy.

Lenalidomidă Dr. Reddy’s should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or any component of the formulation, and patients with uncontrolled active infections or severe renal impairment without dose adjustment. Clinicians must also avoid use in patients who cannot comply with required contraception measures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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