Product image of Lenalidomidă Stada (Lenalidomide) supplied by GNH India

Lenalidomidă Stada

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomidă Stada (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomidă Stada, is an immunomodulatory imide drug (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomidă Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory support for global distribution, shipping products with appropriate documentation to ensure seamless import and clinical use.

Manufacturer / TM Owner

Stada M&d S.R.L.

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Indications & Clinical Uses

  • Lenalidomidă Stada is employed in hematologic malignancies that involve abnormal plasma‑cell proliferation.
  • Multiple myeloma: reduces tumor burden and prolongs progression‑free survival.
  • Myelodysplastic syndromes with del(5q): improves blood counts and lowers transfusion dependence.
  • Mantle cell lymphoma: contributes to disease control when used in combination regimens.

How It Works

  • Lenalidomide binds to the cereblon subunit of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This triggers ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), modulating cytokine production, enhancing T‑cell and natural‑killer‑cell activity, and inhibiting angiogenesis, collectively producing anti‑myeloma effects.

Side Effects

Lenalidomidă Stada may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue or weakness.
  • Nausea, vomiting or loss of appetite.
  • Diarrhea or constipation.
  • Rash or pruritus.
  • Low neutrophil count (neutropenia).
  • Low platelet count (thrombocytopenia).

Serious or Rare Side Effects

  • Thromboembolic events such as deep‑vein thrombosis or pulmonary embolism.
  • Severe neutropenia or infections requiring hospitalization.
  • Secondary primary malignancies, including acute leukemias.

Precautions & Warnings

  • When prescribing Lenalidomidă Stada, clinicians should consider several safety measures to minimize risk.
  • Pregnancy risk: contraindicated in pregnancy (Category X); ensure effective contraception.
  • Thromboembolism: assess individual risk and consider prophylactic anticoagulation.
  • Hematologic monitoring: perform regular complete blood counts to detect neutropenia or thrombocytopenia.
  • Renal impairment: evaluate renal function and adjust dosing as needed.
  • Drug interactions: review concomitant medications for CYP or anticoagulant effects.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Lenalidomidă Stada can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin) – may markedly reduce lenalidomide exposure.
  • Anticoagulants such as warfarin – increased risk of bleeding.
  • Immunosuppressants (e.g., cyclosporine) – may heighten toxicity.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin) – monitor for additive bleeding risk.
  • Live attenuated vaccines – avoid due to potential immunosuppression.
  • Other IMiDs (e.g., thalidomide, pomalidomide) – concurrent use is not recommended.

Frequently Asked Questions

Lenalidomidă Stada contains lenalidomide, an immunomodulatory agent indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes that have a del(5q) chromosomal abnormality, and mantle cell lymphoma, usually as part of a combination chemotherapy regimen.

Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, causing selective degradation of transcription factors Ikaros and Aiolos. This modulates cytokine release, enhances T‑cell and NK‑cell immune responses, and inhibits angiogenesis, together producing anti‑cancer activity in plasma‑cell disorders.

The specific dose and schedule of Lenalidomidă Stada are determined by the treating physician based on the patient’s diagnosis, disease stage, renal function, and concomitant therapies. Prescribers follow approved labeling and clinical guidelines to individualise therapy.

Lenalidomidă Stada is classified as pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal harm. Women of child‑bearing potential must use effective contraception, and breastfeeding is not recommended while receiving the drug.

To order Lenalidomidă Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The primary alternatives to lenalidomide are thalidomide and pomalidomide, which belong to the same immunomodulatory imide drug (IMiD) class. Lenalidomide generally offers a more favorable safety profile than thalidomide, with lower rates of peripheral neuropathy, while providing comparable anti‑myeloma efficacy. Pomalidomide is often reserved for patients who have progressed after lenalidomide therapy.

Lenalidomidă Stada tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister or bottle, protected from moisture, light and excessive heat. Keep the container tightly closed and out of reach of children.

Lenalidomidă Stada is administered orally, usually once daily, with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

The most serious risks include thromboembolic events (deep‑vein thrombosis, pulmonary embolism), severe neutropenia or infections, and the development of secondary primary malignancies such as acute leukemias. Patients should be monitored closely for signs of clotting, fever, or unexplained bleeding.

Lenalidomidă Stada should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or any excipients, and patients with uncontrolled severe renal impairment unless dose adjustments are made. Caution is also advised for patients with a history of thromboembolic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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