Product image of Lenalidomide Accord (Lenalidomide) supplied by GNH India

Lenalidomide Accord

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Accord (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Accord, is an immunomodulatory drug presented as an oral formulation for systemic use. It is indicated for the treatment of multiple myeloma and certain myelodysplastic syndromes in adult patients.

GNH India supplies Lenalidomide Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies and related bone‑marrow disorders.
  • Multiple Myeloma: improves disease control and prolongs survival in patients with relapsed or refractory disease.
  • Myelodysplastic Syndromes: reduces transfusion dependence and delays progression to acute leukemia in selected high‑risk patients.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, leading to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos. This results in modulation of cytokine production, inhibition of angiogenesis, enhanced natural killer cell activity, and direct anti‑myeloma cytotoxicity.

Side Effects

Lenalidomide may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Neutropenia: reduced neutrophil count, increasing infection risk.
  • Thrombocytopenia: low platelet levels, leading to easy bruising.
  • Diarrhea: loose stools that may be mild to moderate.
  • Constipation: difficulty passing stool.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe neutropenia: markedly low neutrophils requiring medical intervention.
  • Severe thrombocytopenia: dangerous drop in platelets.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatotoxicity: liver enzyme elevations or injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • Before initiating Lenalidomide, several safety considerations should be addressed.
  • Dose adjustment: assess renal function and modify dose accordingly.
  • Pregnancy risk: contraindicated in pregnancy; enforce effective contraception for both patient and partner.
  • Infection monitoring: watch for signs of infection and treat promptly.
  • Thromboembolism prophylaxis: consider anticoagulation in patients with additional risk factors.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lenalidomide exposure and toxicity.
  • Anticoagulants (e.g., warfarin): may heighten bleeding risk.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce lenalidomide plasma levels.
  • Immunosuppressants (e.g., cyclosporine): may amplify immunosuppressive effects.
  • Live vaccines: increased risk of infection due to immune modulation.

Frequently Asked Questions

Lenalidomide Accord is prescribed for adult patients with multiple myeloma, particularly in relapsed or refractory settings, and for certain high‑risk myelodysplastic syndromes where it helps reduce transfusion needs and delays disease progression.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase, triggering degradation of transcription factors Ikaros and Aiolos. This alters cytokine signaling, inhibits new blood‑vessel formation, enhances natural killer cell activity, and directly induces death of malignant plasma cells.

The specific dose and schedule of Lenalidomide Accord are determined by the treating physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Only a qualified prescriber can set the appropriate regimen.

Lenalidomide is classified as contraindicated in pregnancy because of a high risk of fetal harm. Women of child‑bearing potential must use effective contraception, and breastfeeding is not recommended while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class and offers a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It is often used in combination regimens and may provide benefit in patients who have progressed after other standard therapies.

Lenalidomide Accord should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Lenalidomide Accord is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and whether it is taken on an empty stomach depend on the individual treatment plan.

The most serious risks include severe neutropenia or thrombocytopenia, which can lead to infection or bleeding, and venous thromboembolism such as deep‑vein thrombosis or pulmonary embolism. Patients should be monitored closely for these events.

Lenalidomide Accord should not be used by individuals who are pregnant, have uncontrolled infections, or have severe renal impairment without dose adjustment. It is also contraindicated in patients with known hypersensitivity to lenalidomide or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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