Product image of Lenalidomide Eg (Lenalidomide) supplied by GNH India

Lenalidomide Eg

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Eg (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Eg, is a immunomodulatory imide drug (IMiD) presented as an oral tablet for oral use. It treats multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma in adult patients. It belongs to the antineoplastic therapeutic class and is administered under medical supervision.

GNH India supplies Lenalidomide Eg as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU GMP standards and providing reliable sourcing for hospitals, oncology centres, pharmacies and clinics worldwide. The product is manufactured in the European Union and distributed under strict quality‑assurance protocols.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory agent used in hematologic malignancies.

  • Multiple Myeloma: improves progression‑free survival and overall response rates in adult patients with relapsed or refractory disease.
  • Myelodysplastic Syndromes with del(5q): reduces transfusion dependence and improves peripheral blood counts in affected adults.
  • Mantle Cell Lymphoma: induces remission and prolongs disease control in relapsed or refractory cases.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, which results in anti‑angiogenic activity, modulation of immune cell function, and direct anti‑tumor effects in malignant cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Neutropenia: lowered neutrophil count increasing infection risk.
  • Thrombocytopenia: reduced platelet count leading to easy bruising.
  • Diarrhea: loose stools that may be mild to moderate.
  • Constipation: difficulty passing stools.
  • Rash: skin redness or itching.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe neutropenia: markedly low neutrophils requiring medical intervention.
  • Severe infections: opportunistic or life‑threatening bacterial, viral or fungal infections.
  • Second primary malignancies: emergence of new cancers unrelated to original disease.
  • Teratogenicity: potential to cause fetal malformations if exposure occurs during pregnancy.

Precautions & Warnings

Prior to initiating Lenalidomide therapy, several precautions should be observed to ensure patient safety.

  • Pregnancy: contraindicated (Category X) due to high teratogenic risk; effective contraception required.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation.
  • Renal impairment: evaluate kidney function and adjust dose if necessary.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Drug interactions: avoid concomitant use with strong CYP3A4 inducers and monitor with anticoagulants.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may markedly reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: heightened risk of infection due to immunosuppression.
  • Pregnancy: co‑administration with teratogenic agents compounds fetal risk.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may increase lenalidomide plasma levels; monitor for toxicity.
  • NSAIDs: combined use may elevate risk of renal impairment and gastrointestinal bleeding.

Frequently Asked Questions

Lenalidomide Eg is indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes that carry the del(5q) cytogenetic abnormality, and mantle cell lymphoma. In each condition it is used to improve disease control, reduce dependence on transfusions, or achieve remission when other therapies have failed.

Lenalidomide binds to the cereblon protein, part of the CRL4‑CRBN E3 ubiquitin ligase complex. This binding changes the complex’s target specificity, leading to the degradation of transcription factors Ikaros and Aiolos. The resulting actions include anti‑angiogenic effects, modulation of immune cell activity, and direct inhibition of malignant cell growth.

The dose of Lenalidomide Eg is individualized and must be prescribed by a qualified healthcare professional. The prescriber determines the appropriate strength, schedule, and duration based on the specific indication, patient characteristics, and any relevant laboratory values.

Lenalidomide is classified as Pregnancy Category X because it has a high risk of causing fetal malformations and embryotoxicity. It is contraindicated during pregnancy, and effective contraception is required for both male and female patients of reproductive potential. Safety during breastfeeding has not been established, and nursing is generally discouraged.

To place an order, submit an enquiry on the Lenalidomide Eg product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Lenalidomide belongs to the immunomodulatory imide drug (IMiD) class, sharing a similar mechanism with thalidomide but offering greater potency and a more favorable safety profile, especially regarding peripheral neuropathy. Compared with conventional chemotherapy, Lenalidomide provides targeted immunomodulation and anti‑angiogenic effects, often resulting in improved response rates and tolerability in the approved hematologic cancers.

Lenalidomide Eg should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and excessive heat. Do not store in the bathroom or near a kitchen sink. Ensure the packaging remains sealed until use to maintain product integrity.

Lenalidomide Eg is administered orally, typically as a tablet taken with water. The medication may be taken with or without food, depending on the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and should not alter the timing or skip doses without medical advice.

The most serious risks include venous thromboembolism (blood clots), severe neutropenia or other cytopenias that increase infection risk, life‑threatening infections, second primary malignancies, and teratogenic effects that can cause fetal birth defects. Patients should be monitored regularly for signs of these events and seek immediate medical attention if they occur.

Lenalidomide Eg is contraindicated in pregnant women and in any individual who cannot use effective contraception during treatment. It should also be avoided in patients with known hypersensitivity to lenalidomide or any component of the formulation, and in those with uncontrolled severe infections or uncontrolled thrombotic disorders without appropriate prophylaxis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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