Product image of Lenalidomide Eugia (Lenalidomide) supplied by GNH India

Lenalidomide Eugia

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Eugia (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Eugia, is an immunomodulatory agent presented as a tablet for oral use. It treats certain blood cancers such as multiple myeloma, myelodysplastic syndromes with del(5q), mantle cell lymphoma and follicular lymphoma in adult patients.

GNH India supplies Lenalidomide Eugia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies, clinics and research institutions worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Lenalidomide is indicated for several hematologic malignancies and works by targeting disease‑specific pathways.

  • Multiple Myeloma: helps control disease progression and prolong survival.
  • Myelodysplastic Syndromes with del(5q): reduces transfusion dependence and improves blood counts.
  • Mantle Cell Lymphoma: contributes to tumor reduction in relapsed or refractory cases.
  • Follicular Lymphoma: used in patients with disease that has progressed after prior therapy.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that suppress malignant plasma cells and other lymphoid tumor cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Diarrhea: loose stools that may require supportive care.
  • Rash: skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe neutropenia or thrombocytopenia: markedly low blood cell counts.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatotoxicity: liver enzyme elevations indicating liver injury.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline health status and monitor for specific risks.

  • Monitor blood counts: perform regular CBCs to detect cytopenias.
  • Assess thrombotic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Contraindicated in pregnancy: strict contraception required for women of childbearing potential.
  • Adjust for renal impairment: dose modifications may be needed in reduced kidney function.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomide interacts with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may lower lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: heightened risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise drug levels.
  • NSAIDs: additive risk of gastrointestinal bleeding.
  • Digoxin: potential for increased serum concentrations.

Frequently Asked Questions

Lenalidomide Eugia is prescribed for adult patients with multiple myeloma, myelodysplastic syndromes that have the del(5q) chromosomal abnormality, mantle cell lymphoma and follicular lymphoma. It is used when disease control or improvement is needed, often after other therapies have been tried.

The drug binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex. This binding changes the complex’s target profile, leading to the degradation of transcription factors Ikaros and Aiolos. The resulting anti‑angiogenic, immunomodulatory, and anti‑proliferative actions suppress malignant blood‑cell growth.

The specific dose and schedule of Lenalidomide Eugia are determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function and other individual factors. Healthcare professionals should follow the latest clinical guidelines and product labeling when prescribing.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. Women of childbearing potential must use effective contraception. The safety of Lenalidomide during breastfeeding has not been established, and nursing is generally discouraged.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug (IMiD) class, offering a distinct mechanism from proteasome inhibitors or monoclonal antibodies. It is often combined with dexamethasone or used after other regimens. Compared with older agents, Lenalidomide provides oral administration and a different side‑effect profile, but choice of therapy depends on individual patient factors and prior treatment history.

Lenalidomide Eugia tablets should be stored at room temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the package is tightly closed to maintain stability.

The medication is taken orally, usually once daily, with or without food as directed by the prescriber. Patients should swallow the tablet whole with water and follow any specific timing instructions provided by their healthcare professional.

Serious risks include venous thromboembolism, severe neutropenia or thrombocytopenia, secondary primary malignancies, and liver toxicity. Patients should be monitored closely for signs of blood clots, infections, abnormal bleeding, and liver function changes throughout treatment.

Lenalidomide is contraindicated in pregnant women, individuals with known hypersensitivity to the drug or its excipients, and patients with severe renal impairment unless dose‑adjusted. It should also be avoided in patients receiving live vaccines due to the risk of infection.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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