Product image of Lenalidomide Faran (Lenalidomide) supplied by GNH India

Lenalidomide Faran

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Faran (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Faran, is a immunomodulatory drug (IMiD) presented as an oral tablet for oral use. It treats multiple myeloma, myelodysplastic syndromes with del(5q) and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomide Faran as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Faran S.A.

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies that involve abnormal plasma cell or lymphoid proliferation.

  • Multiple myeloma: improves progression‑free survival and overall response rates in eligible patients.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and induces cytogenetic remission.
  • Mantle cell lymphoma: enhances response when combined with rituximab in relapsed or refractory disease.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4A9 E3 ubiquitin ligase complex, altering substrate specificity. This leads to degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and direct anti‑tumor activities that inhibit malignant cell proliferation.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools that may lead to dehydration.
  • Rash: skin redness or itching.

Serious or Rare Side Effects

  • Thromboembolic events: blood clots such as deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly reduced neutrophil count increasing infection risk.
  • Secondary malignancies: emergence of new cancers, including acute myeloid leukemia.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Pregnancy contraindication: drug is classified Category X; avoid use in pregnancy.
  • Teratogenic risk: ensure effective contraception for both male and female patients of reproductive potential.
  • Blood count monitoring: perform regular CBC to detect neutropenia or anemia.
  • Thromboembolism prophylaxis: assess risk and consider anticoagulation in high‑risk patients.
  • Renal impairment adjustment: evaluate kidney function and modify dosing as needed.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Lenalidomide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lenalidomide exposure.
  • P‑glycoprotein inhibitors (e.g., verapamil): can raise plasma concentrations.
  • Anticoagulants (e.g., warfarin) when combined with high thrombotic risk: may exacerbate clotting.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Other myelosuppressive agents (e.g., chemotherapy): increase risk of cytopenias.
  • Live vaccines: reduced efficacy and potential infection risk.

Frequently Asked Questions

Lenalidomide Faran is indicated for the treatment of multiple myeloma, myelodysplastic syndromes that carry the del(5q) cytogenetic abnormality, and mantle cell lymphoma. These are hematologic cancers where the drug’s immunomodulatory and anti‑angiogenic actions help control disease progression.

Lenalidomide binds to cereblon, a component of the CRL4A9 E3 ubiquitin ligase complex, altering its substrate specificity. This triggers degradation of transcription factors such as Ikaros and Aiolos, leading to reduced tumor cell proliferation, inhibition of new blood‑vessel formation, and enhanced immune‑mediated tumor cell killing.

The specific dose of Lenalidomide Faran is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Dosing regimens are individualized and should follow the prescriber’s instructions and any local regulatory guidelines.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of known teratogenic risk. It should not be used by breastfeeding mothers, and effective contraception is required for both male and female patients of reproductive potential during treatment and for a defined period after discontinuation.

To order Lenalidomide Faran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory drug (IMiD) class, but lenalidomide is more potent, has a shorter half‑life, and generally exhibits a more favorable safety profile, especially regarding peripheral neuropathy. Lenalidomide also shows stronger anti‑angiogenic activity and is the preferred option for the approved indications listed above.

Store Lenalidomide Faran at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and avoid exposure to excessive heat or humidity to maintain product stability.

Lenalidomide Faran is taken orally as a tablet. It may be swallowed with or without food, according to the prescriber’s guidance. Patients should follow the dosing schedule provided by their healthcare professional and not alter the timing or frequency without medical advice.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe neutropenia that can predispose to infections, and the potential development of secondary malignancies like acute myeloid leukemia. Patients should be monitored closely for these complications throughout therapy.

Lenalidomide Faran should not be used by pregnant women or by anyone who cannot adhere to strict contraceptive measures. Patients with uncontrolled severe renal impairment, active uncontrolled infections, or a history of hypersensitivity to lenalidomide should avoid the medication unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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