Product image of Lenalidomide Glenmark (Lenalidomide) supplied by GNH India

Lenalidomide Glenmark

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Glenmark (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Glenmark, is an immunomodulatory drug (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes with del(5q) in adult patients. The product complies with EU GMP standards and is intended for oncology practice in hospitals and specialized treatment centres.

GNH India supplies Lenalidomide Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring reliable quality and regulatory compliance.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

  • Lenalidomide is an immunomodulatory agent used in specific hematologic malignancies.
  • Multiple myeloma: improves disease control and prolongs progression‑free survival in adult patients.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and improves hematologic parameters.
  • Mantle cell lymphoma (relapsed/refractory): contributes to tumor response when combined with other therapies.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity and promoting ubiquitination and proteasomal degradation of transcription factors such as Ikaros (IKZF1) and Aiolos (IKZF3). This leads to modulation of cytokine production, inhibition of angiogenesis, and enhancement of T‑cell and natural‑killer cell mediated immune responses, collectively producing anti‑tumor activity in malignant plasma cells and dysplastic clones.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue
  • Neutropenia
  • Thrombocytopenia
  • Anemia
  • Diarrhea
  • Rash

Serious or Rare Side Effects

  • Venous thromboembolism
  • Severe neutropenia
  • Severe thrombocytopenia
  • Secondary primary malignancies
  • Severe allergic reactions (anaphylaxis)
  • Liver toxicity (elevated transaminases)

Precautions & Warnings

When prescribing Lenalidomide, clinicians should observe several safety measures to minimize risk.

  • Monitor blood counts: perform regular complete blood count assessments to detect cytopenias.
  • Assess thrombotic risk: evaluate patient history and consider prophylactic anticoagulation when appropriate.
  • Evaluate renal function: adjust dosing in patients with impaired clearance.
  • Avoid pregnancy: ensure effective contraception for both male and female patients of reproductive potential.
  • Review concomitant medications: check for drugs that may increase toxicity or reduce efficacy.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture.

Avoid Interactions

Lenalidomide interacts with several medicines; awareness of major and moderate interactions helps guide safe co‑administration.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lenalidomide exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may enhance bleeding tendency.
  • Digoxin: may increase serum levels.
  • CYP3A4 substrate drugs (e.g., midazolam): may have altered concentrations.

Frequently Asked Questions

Lenalidomide Glenmark is prescribed for adult patients with multiple myeloma and for those with myelodysplastic syndromes that carry the del(5q) chromosomal abnormality. In these settings it helps control disease progression, reduce the need for blood transfusions, and improve overall blood cell counts.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, changing the complex’s target profile. This triggers degradation of specific transcription factors, leading to reduced cytokine production, inhibition of new blood‑vessel formation, and enhanced activity of T‑cells and natural‑killer cells, which together produce anti‑tumor effects.

The dosage of Lenalidomide Glenmark is individualized by the treating physician based on the specific indication, patient characteristics, and laboratory parameters. Only a qualified prescriber can determine the appropriate strength, schedule, and duration of therapy.

Lenalidomide is classified as a high‑risk medication for fetal harm. Women of child‑bearing potential must use effective contraception, and the drug should not be used during pregnancy. Safety during breastfeeding has not been established, so breastfeeding is generally discouraged while on therapy.

To request Lenalidomide Glenmark, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs), and the necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class and is often used in combination with dexamethasone or proteasome inhibitors. Compared with traditional chemotherapy, it offers a different mechanism—modulating the immune system and inhibiting angiogenesis—while providing comparable efficacy in many patients and a distinct side‑effect profile.

Store Lenalidomide Glenmark at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Lenalidomide Glenmark is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and whether it should be taken on an empty stomach depend on the individual treatment plan.

Serious risks include severe neutropenia, severe thrombocytopenia, venous thromboembolism, secondary primary cancers, and severe allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of infection, bleeding, or clot formation, and any concerning symptoms should be reported immediately.

Lenalidomide Glenmark should be avoided in patients with known hypersensitivity to lenalidomide or any of its excipients, in those who are pregnant or not using effective contraception, and in individuals with uncontrolled infections or severe organ dysfunction where the risk outweighs potential benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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