Product image of Lenalidomide Grindeks (Lenalidomide) supplied by GNH India

Lenalidomide Grindeks

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Grindeks (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Grindeks, is an Immunomodulatory drug presented as a strength/form for oral use. It treats multiple myeloma, myelodysplastic syndromes with del(5q) and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomide Grindeks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Grindeks

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies that respond to immunomodulatory therapy.
  • Multiple Myeloma: improves progression‑free survival and overall response in relapsed or refractory disease.
  • Myelodysplastic Syndromes with del(5q): induces transfusion independence and cytogenetic remission in eligible patients.
  • Mantle Cell Lymphoma: provides disease control in relapsed or refractory cases as part of combination therapy.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects that inhibit proliferation of malignant plasma cells and other hematologic cancer cells.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Fatigue
  • Neutropenia
  • Diarrhea

Serious or Rare Side Effects

  • Venous thromboembolism
  • Severe infections
  • Secondary primary malignancies

Precautions & Warnings

  • Lenalidomide requires careful monitoring and risk mitigation.
  • Pregnancy: contraindicated (Category X); ensure effective contraception.
  • Thrombosis risk: assess patient history and consider prophylaxis.
  • Hematologic monitoring: perform regular complete blood counts.
  • Renal impairment: dose adjustment may be necessary.
  • Drug interactions: avoid concomitant use with strong CYP3A4 inducers.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Lenalidomide can interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may markedly reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents: monitor for bleeding complications.
  • Immunosuppressants: watch for heightened infection risk.
  • Diuretics: monitor electrolyte balance and renal function.

Frequently Asked Questions

Lenalidomide Grindeks is indicated for adult patients with multiple myeloma, myelodysplastic syndromes that have a deletion of chromosome 5q, and mantle cell lymphoma, typically when the disease is relapsed or refractory.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its activity. This triggers degradation of specific transcription factors, leading to anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects that suppress malignant cell growth.

The prescribed dose of Lenalidomide Grindeks is determined by the treating physician based on the specific indication, disease stage, renal function, and patient tolerance. Dosing regimens are individualized and should follow the prescriber’s instructions.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. It is also not recommended during breastfeeding because it may be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism of action compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration and can be combined with other agents, whereas alternatives may require intravenous infusion or have different safety profiles.

Store Lenalidomide Grindeks at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lenalidomide Grindeks is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact schedule (e.g., daily or on specific days of a cycle) is individualized based on the treatment plan.

Serious risks include venous thromboembolism, severe neutropenia or infections, and the potential for secondary primary malignancies. Patients should be monitored closely for signs of blood clots, infections, and any unexpected symptoms.

Lenalidomide Grindeks should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled severe infections or certain contraindicated drug interactions. The prescriber will assess suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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