Product image of Lenalidomide Olainfarm (Lenalidomide) supplied by GNH India

Lenalidomide Olainfarm

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Olainfarm (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Olainfarm, is an immunomodulatory imide drug (IMiD) presented as an appropriate‑strength tablet for oral use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes, and mantle‑cell lymphoma in adult patients.

GNH India supplies Lenalidomide Olainfarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide, with a focus on quality assurance and regulatory compliance. Our distribution network ensures timely delivery and support for clinical programs across multiple regions.

Manufacturer / TM Owner

Jsc Olainfarm

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies to control disease progression and improve survival.
  • Multiple myeloma: reduces tumor burden, delays disease progression, and prolongs progression‑free and overall survival in eligible adult patients.
  • Myelodysplastic syndromes with del(5q): improves red blood cell production, corrects anemia, and reduces the need for blood transfusions in patients with this cytogenetic abnormality.
  • Mantle cell lymphoma: induces tumor regression, achieves partial or complete remission, and extends overall survival in relapsed or refractory cases.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, altering substrate specificity and leading to degradation of transcription factors such as Ikaros and Aiolos. This results in modulation of cytokine production, inhibition of angiogenesis, and activation of T‑ and NK‑cell mediated immune responses, ultimately inducing apoptosis of malignant plasma cells and other hematologic tumor cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels leading to bleeding tendency.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require supportive care.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Secondary primary malignancies: emergence of new cancers.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating Lenalidomide therapy, several precautions should be considered to ensure patient safety.

  • Pregnancy: contraindicated; effective contraception required for both patient and male partners.
  • Renal impairment: dose adjustment may be needed based on creatinine clearance.
  • Hematologic monitoring: regular blood counts to detect neutropenia or thrombocytopenia.
  • Thromboembolic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Drug interactions: review concomitant medications for CYP or immunomodulatory effects.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce plasma concentrations.
  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): increased risk of bleeding.
  • Immunosuppressants (e.g., cyclosporine): may enhance immunosuppressive effects.

Moderate Interactions (Monitor Closely)

  • P-glycoprotein substrates (e.g., digoxin): possible altered levels.
  • Vaccines (live attenuated): reduced vaccine efficacy; avoid during therapy.
  • Other myelosuppressive agents (e.g., chemotherapy): additive bone marrow suppression.

Frequently Asked Questions

Lenalidomide Olainfarm is prescribed for adult patients with multiple myeloma, myelodysplastic syndromes that carry a del(5q) chromosome abnormality, and mantle‑cell lymphoma. In each indication the drug aims to reduce tumor burden, improve blood counts, and extend survival when used as part of an approved treatment regimen.

The molecule binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex. This binding changes the complex’s substrate profile, leading to degradation of transcription factors such as Ikaros and Aiolos. The downstream effect is modulation of cytokine release, inhibition of new blood‑vessel formation, and activation of immune cells that together trigger apoptosis of malignant cells.

The exact dose is set by the prescribing clinician based on the specific indication, patient weight, renal function, and prior treatment history. Dosing may be adjusted for renal impairment or when combined with other myelosuppressive agents, and the prescriber will follow the relevant clinical guidelines for each disease state.

Lenalidomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal harm. Women of child‑bearing potential must use effective contraception, and breastfeeding is not recommended while taking the drug or for a period after the last dose as advised by the prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Lenalidomide belongs to the immunomodulatory imide drug (IMiD) class, sharing a similar mechanism with thalidomide and pomalidomide. Compared with thalidomide, Lenalidomide generally shows higher potency, a more favorable side‑effect profile, and less peripheral neuropathy. Pomalidomide is a newer IMiD often reserved for patients who have progressed after Lenalidomide therapy.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect the product from moisture, direct sunlight, and excessive heat. Do not refrigerate or freeze the tablets, and keep them out of reach of children.

Lenalidomide Olainfarm is taken orally as a whole tablet, usually once daily on a schedule defined by the prescriber. It may be taken with or without food, but patients should follow any specific instructions regarding timing relative to meals or other medications.

The most critical safety concerns include severe neutropenia or thrombocytopenia, which can lead to infection or bleeding, and an increased risk of venous thromboembolism. Additionally, secondary primary malignancies have been reported, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome may occur. Prompt medical attention is required if any of these events arise.

Lenalidomide should not be used by pregnant women or by women who could become pregnant without reliable contraception. Patients with known hypersensitivity to Lenalidomide or any of its excipients should avoid the drug. Caution is also advised for individuals with severe renal impairment, uncontrolled infections, or a history of thromboembolic events unless appropriate prophylaxis is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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