Product image of Lenalidomide Pharmascience (Lenalidomide) supplied by GNH India

Lenalidomide Pharmascience

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Pharmascience (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Pharmascience, is an immunomodulatory antineoplastic presented as an oral formulation for systemic use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes with a del(5q) chromosome abnormality, typically in adult patients.

GNH India supplies Lenalidomide Pharmascience as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmascience International Ltd

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Indications & Clinical Uses

  • Lenalidomide is used in hematologic malignancies that respond to immunomodulatory therapy.
  • Multiple myeloma: improves progression‑free and overall survival in newly diagnosed and relapsed disease.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and cytopenias.
  • Maintenance after autologous stem‑cell transplant in multiple myeloma: prolongs remission duration.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, prompting ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos. This leads to anti‑proliferative, pro‑apoptotic and anti‑angiogenic effects on malignant plasma cells and dysplastic hematopoietic clones.

Side Effects

Lenalidomide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Neutropenia: reduced neutrophil counts.
  • Fatigue: persistent tiredness.
  • Diarrhea: loose stools.
  • Rash: skin irritation or erythema.
  • Constipation: difficulty passing stool.
  • Nausea: feeling of sickness.

Serious or Rare Side Effects

  • Thromboembolic events: deep‑vein thrombosis or pulmonary embolism.
  • Severe neutropenia: heightened infection risk.
  • Serious infections: opportunistic or bacterial infections.
  • Secondary malignancies: emergence of new cancers.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor laboratory parameters.

  • Pregnancy: contraindicated; category X, require effective contraception.
  • Thrombosis risk: assess history and consider prophylactic anticoagulation.
  • Renal function: adjust monitoring in impaired patients.
  • Hepatic function: monitor liver enzymes regularly.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

  • Live vaccines: may cause uncontrolled infection.
  • Strong CYP3A4 inducers (e.g., rifampin): may reduce drug exposure.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): increased bleeding risk.
  • Antihypertensives: potential additive hypotensive effect.
  • Immunosuppressants (e.g., cyclosporine): heightened infection susceptibility.

Frequently Asked Questions

Lenalidomide Pharmascience is indicated for adult patients with multiple myeloma and for myelodysplastic syndromes that carry a del(5q) chromosome abnormality. It may also be used as maintenance therapy after stem‑cell transplantation in multiple myeloma.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex. This binding triggers the degradation of transcription factors Ikaros and Aiolos, leading to reduced proliferation, increased apoptosis, and inhibition of angiogenesis in malignant plasma cells and dysplastic clones.

The specific dose and schedule of Lenalidomide Pharmascience are determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Patients should follow the prescriber’s instructions precisely.

Lenalidomide is classified as pregnancy category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. Women of child‑bearing potential must use effective contraception, and breastfeeding is not recommended while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism of action compared with proteasome inhibitors or monoclonal antibodies. It is often combined with dexamethasone or used in combination regimens, providing synergistic anti‑myeloma activity and a different side‑effect profile.

Store Lenalidomide Pharmascience at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed when not in use.

Lenalidomide Pharmascience is taken orally, usually once daily, with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

The most serious risks include severe neutropenia, thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, serious infections, secondary malignancies, and hepatotoxicity. Patients should be monitored regularly for blood counts, liver function and signs of clotting.

Lenalidomide should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled active infections. Caution is also advised for those with severe renal or hepatic impairment, and the drug is contraindicated with live vaccines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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