Product image of Lenalidomide Qilu (Lenalidomide) supplied by GNH India

Lenalidomide Qilu

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Qilu (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Qilu, is an immunomodulatory agent presented as an oral tablet for oral use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes in adult patients.

GNH India supplies Lenalidomide Qilu as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics across multiple regions. The company adheres to stringent manufacturing standards and provides comprehensive support for product registration and post‑marketing surveillance.

Manufacturer / TM Owner

Qilu Pharma Spain S.L.

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory antineoplastic used in hematologic malignancies and related bone‑marrow disorders.

  • Multiple myeloma: improves progression‑free survival and overall response rates in adult patients.
  • Relapsed/refractory multiple myeloma: provides a therapeutic option after prior therapies.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and induces cytogenetic remission.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, altering its substrate specificity. This leads to the degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that inhibit tumor growth and modulate the immune microenvironment.

Side Effects

Common Side Effects

  • Neutropenia: decreased neutrophil count increasing infection risk.
  • Thrombocytopenia: reduced platelet levels that may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Constipation: difficulty passing stool.
  • Rash: mild skin irritation or erythema.
  • Nausea: upset stomach and possible vomiting.

Serious or Rare Side Effects

  • Venous thromboembolism: formation of blood clots in veins.
  • Severe neutropenia: markedly low neutrophil counts leading to serious infections.
  • Severe infections: opportunistic or bacterial infections requiring hospitalization.
  • Second primary malignancies: emergence of new cancers unrelated to the original disease.
  • Tumor lysis syndrome: rapid tumor cell breakdown causing metabolic disturbances.
  • Hypersensitivity reactions: severe allergic responses including anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Dose adjustment in renal impairment: assess renal function and modify dose accordingly.
  • Monitor blood counts regularly: watch for neutropenia, thrombocytopenia, and anemia.
  • Assess thrombotic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Avoid use in pregnancy: teratogenic potential requires strict contraception.
  • Store at ambient temperature: keep below 25 °C, protect from moisture in original packaging.

Avoid Interactions

Lenalidomide may interact with several drug classes. Review patient medication lists carefully.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lenalidomide exposure and efficacy.
  • Anticoagulants: increased risk of bleeding when combined.
  • Live vaccines: heightened infection risk due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • P‑glycoprotein inhibitors: may increase plasma concentrations of lenalidomide.
  • Other immunosuppressants: additive myelosuppression potential.
  • Hormonal contraceptives: may reduce contraceptive effectiveness, requiring additional barrier methods.

Frequently Asked Questions

Lenalidomide Qilu is prescribed for adult patients with multiple myeloma, including relapsed or refractory disease, and for myelodysplastic syndromes that have the del(5q) chromosomal abnormality. In these settings, it helps control disease progression and can reduce the need for blood transfusions.

Lenalidomide binds to cereblon, a component of the CRL4 E3 ubiquitin ligase complex, changing its activity. This triggers the degradation of specific transcription factors, leading to anti‑angiogenic, immunomodulatory, and anti‑proliferative actions that suppress malignant cell growth and modify the immune response.

The dose is individualized by the prescribing clinician based on the specific indication, the patient’s renal function, prior therapies, and overall health status. No fixed regimen is provided here; the prescriber will calculate the appropriate amount and schedule for each patient.

Lenalidomide is classified as teratogenic and is contraindicated in pregnancy. Women of child‑bearing potential must use effective contraception during treatment and for a defined period after the last dose. Safety during breastfeeding has not been established, so breastfeeding is generally discouraged.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both lenalidomide and thalidomide belong to the same immunomodulatory class, but lenalidomide is more potent, has a more favorable safety profile, and exhibits stronger anti‑angiogenic and anti‑myeloma activity. Thalidomide is associated with higher rates of peripheral neuropathy, whereas lenalidomide’s main concerns are hematologic toxicities.

Store Lenalidomide Qilu at ambient temperature, preferably below 25 °C (77 °F). Keep the tablets in the original container, protect them from moisture and direct sunlight, and avoid storing them in bathrooms or other humid environments.

Lenalidomide Qilu is taken orally as a tablet, usually once daily. It can be swallowed with or without food, but patients should follow the specific instructions provided by their healthcare professional regarding timing and any required dose adjustments.

The most serious risks include severe neutropenia, which can lead to life‑threatening infections; venous thromboembolism, which may cause deep‑vein thrombosis or pulmonary embolism; and the potential for second primary malignancies. Patients should be monitored closely for signs of infection, clotting, or new cancer development.

Lenalidomide Qilu should not be used by individuals who are pregnant, nursing, or have known hypersensitivity to the drug or its excipients. It is also contraindicated in patients with uncontrolled severe infections or those who cannot adhere to required contraceptive measures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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