Product image of Lenalidomide Ranbaxy (Lenalidomide) supplied by GNH India

Lenalidomide Ranbaxy

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Ranbaxy (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Ranbaxy, is an immunomodulatory drug (IMiD) presented as an oral formulation for oral use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes in adult patients who have relapsed or refractory disease and require systemic therapy.

GNH India supplies Lenalidomide Ranbaxy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Ranbaxy Poland Sp. Zo.O

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory agent used in hematologic malignancies.

  • Multiple myeloma (newly diagnosed): enhances response rates when combined with dexamethasone.
  • Multiple myeloma (relapsed/refractory): provides disease control after prior therapies.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and can induce cytogenetic remission.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, leading to selective degradation of transcription factors Ikaros and Aiolos. This modulates cytokine production, enhances T‑cell and NK‑cell mediated immunity, inhibits angiogenesis, and triggers apoptosis of malignant plasma cells and dysplastic progenitors.

Side Effects

Lenalidomide may cause a range of adverse reactions.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Diarrhea: loose stools that may require fluid replacement.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe neutropenia: profound drop in neutrophils requiring medical intervention.
  • Secondary primary malignancies: emergence of new cancers unrelated to the original disease.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood counts: perform regular CBC to detect cytopenias.
  • Assess thrombotic risk: evaluate history of clotting disorders and consider prophylaxis.
  • Contraindicated in pregnancy: avoid use in pregnant women and ensure effective contraception.
  • Adjust for renal impairment: dose may need modification in reduced kidney function.
  • Counsel on contraception: both male and female patients must use reliable birth control.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lenalidomide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may lower lenalidomide exposure.
  • Live vaccines: increased risk of infection due to immunomodulation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise drug levels.
  • Anticoagulants (e.g., warfarin): heightened risk of thrombosis.
  • NSAIDs: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Lenalidomide Ranbaxy is prescribed for adult patients with multiple myeloma, including newly diagnosed and relapsed/refractory cases, as well as for myelodysplastic syndromes that have the del(5q) chromosomal abnormality. In these settings, it helps control disease progression and can reduce the need for blood transfusions.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, leading to the targeted degradation of transcription factors Ikaros and Aiolos. This action modifies cytokine production, boosts T‑cell and natural‑killer cell activity, blocks new blood‑vessel formation, and induces programmed cell death in malignant plasma cells and dysplastic bone‑marrow cells.

The specific dose and schedule of Lenalidomide Ranbaxy are determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Healthcare providers follow approved labeling and clinical guidelines to individualize therapy.

Lenalidomide is classified as contraindicated in pregnancy because it can cause fetal harm. Women of child‑bearing potential must use effective contraception before, during, and after treatment. Safety during breastfeeding has not been established, and breastfeeding is generally discouraged while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

The primary alternative to lenalidomide in many hematologic indications is pomalidomide, another immunomodulatory agent with a similar mechanism but a different safety profile and potency. Lenalidomide is often used earlier in treatment sequences, while pomalidomide may be reserved for patients who have progressed after lenalidomide therapy.

Lenalidomide Ranbaxy should be stored at temperatures below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lenalidomide Ranbaxy is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. The tablets are swallowed whole with water and should be taken at the same time each day to maintain consistent drug levels.

The most serious risks include venous thromboembolism (blood clots), severe neutropenia or thrombocytopenia that can lead to infections or bleeding, and the potential development of secondary primary malignancies. Patients should be monitored closely for these events throughout therapy.

Lenalidomide should not be used by individuals who are pregnant, have uncontrolled infections, or have a known hypersensitivity to lenalidomide or any of its excipients. Patients with severe renal impairment may require dose adjustments, and those with a history of thrombotic events should be evaluated carefully before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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