Product image of Lenalidomide Sandoz 10 Mg Hard Capsules (Lenalidomide) supplied by GNH India

Lenalidomide Sandoz 10 Mg Hard Capsules

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Sandoz 10 Mg Hard Capsules (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Sandoz 10 mg hard capsules, is an immunomodulatory imide drug (IMiD) presented as a 10 mg oral capsule for prescription use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma in adult patients, typically within the European Union market.

GNH India supplies Lenalidomide Sandoz 10 mg hard capsules as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, oncology centres, transplant units and pharmacies worldwide through regulated channels, and ensuring compliance with local regulations.

Manufacturer / TM Owner

Sandoz Ltd

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Indications & Clinical Uses

  • Lenalidomide is an immunomodulatory agent used in hematologic malignancies.
  • Multiple Myeloma: improves progression‑free survival and overall response rates in relapsed or refractory disease.
  • Myelodysplastic Syndromes: reduces transfusion dependence and delays transformation to acute leukemia in patients with del(5q) cytogenetic abnormality.
  • Mantle Cell Lymphoma: contributes to disease control in relapsed or refractory cases when combined with other therapies.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity. This triggers ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), leading to modulation of cytokine production, inhibition of angiogenesis, and direct anti‑tumor activity against malignant plasma cells and other hematologic cancer cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require hydration.
  • Rash: mild skin eruptions or itching.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly low neutrophil count increasing infection risk.
  • Hepatotoxicity: elevated liver enzymes or liver injury.

Precautions & Warnings

  • When prescribing Lenalidomide, several precautions should be observed to minimize risks.
  • Pregnancy risk: avoid use in pregnant women; effective contraception required for both male and female patients of reproductive potential.
  • Thrombosis prophylaxis: assess need for anticoagulation in patients with additional risk factors.
  • Renal impairment: adjust monitoring and consider dose modification in patients with reduced kidney function.
  • Hepatic function: monitor liver enzymes regularly, especially in patients with pre‑existing liver disease.
  • Infection monitoring: watch for signs of infection due to neutropenia or immunosuppression.
  • Store at ambient temperature: keep capsules below 25 °C in the original container, protect from moisture and direct light.

Avoid Interactions

Lenalidomide can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding when combined with lenalidomide‑induced thrombocytopenia.
  • Immunosuppressants: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • P-glycoprotein inhibitors: may increase plasma levels of lenalidomide.
  • NSAIDs: additive risk of renal impairment.
  • Vaccines: live attenuated vaccines may be less effective; avoid during therapy.

Frequently Asked Questions

Lenalidomide Sandoz 10 mg hard capsules are prescribed for the treatment of certain blood cancers, specifically multiple myeloma, myelodysplastic syndromes with del(5q) cytogenetic abnormality, and mantle cell lymphoma, usually in adult patients who have relapsed or are refractory to prior therapies.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, changing its substrate specificity. This leads to the degradation of transcription factors Ikaros and Aiolos, which modulates cytokine release, inhibits new blood‑vessel formation, and exerts direct anti‑tumor effects on malignant hematologic cells.

The dosing regimen for Lenalidomide Sandoz 10 mg is determined by the prescribing physician based on the specific indication, disease stage, patient characteristics, and concomitant therapies. Patients should follow the exact dose and schedule provided by their healthcare professional.

Lenalidomide is classified with an unknown pregnancy category, and it is generally contraindicated during pregnancy because of potential fetal harm. Women of child‑bearing potential should use effective contraception, and breastfeeding is not recommended while taking the medication.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required cold‑chain) and import documentation.

The primary alternative to lenalidomide within the IMiD class is thalidomide, while pomalidomide is a newer analogue. Lenalidomide generally offers a more favorable safety profile than thalidomide, with lower rates of peripheral neuropathy, and it provides stronger anti‑angiogenic and immunomodulatory activity compared with earlier agents.

Store Lenalidomide capsules at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct light, and ensure the cap is tightly closed to maintain product stability.

Lenalidomide is taken orally. Patients should swallow each hard capsule whole with water, preferably on an empty stomach unless otherwise directed by their clinician. The medication can be taken with or without food, but consistency with regard to meals helps maintain stable absorption.

Key serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe neutropenia that can predispose to infections, hepatotoxicity indicated by elevated liver enzymes, and the potential development of secondary malignancies. Prompt medical attention is required if any of these occur.

Lenalidomide should not be used by pregnant women, individuals with known hypersensitivity to the drug or its excipients, and patients with severe renal impairment unless a specialist determines a safe approach. Caution is also advised for those with uncontrolled infections or significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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