Product image of Lenalidomide Sandoz 15 Mg Hard Capsules (Lenalidomide) supplied by GNH India

Lenalidomide Sandoz 15 Mg Hard Capsules

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Sandoz 15 Mg Hard Capsules (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Sandoz 15 Mg Hard Capsules, is an immunomodulatory agent presented as a 15 mg hard capsule for oral use. It is indicated for the treatment of certain blood cancers such as multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomide Sandoz 15 Mg Hard Capsules as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Ltd

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies that involve abnormal plasma or lymphoid cells.

  • Multiple myeloma: reduces tumor burden and prolongs progression‑free survival.
  • Myelodysplastic syndromes with del(5q): improves blood counts and reduces transfusion dependence.
  • Mantle cell lymphoma: contributes to disease control in relapsed or refractory cases.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This triggers ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), modulating cytokine production, inhibiting angiogenesis, and enhancing T‑cell and natural‑killer cell immune responses, thereby suppressing malignant cell proliferation.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fatigue: feeling of tiredness or lack of energy.
  • Diarrhea: loose stools occurring intermittently.
  • Constipation: difficulty passing stools.
  • Nausea: sensation of urge to vomit.
  • Rash: mild skin redness or itching.
  • Low blood counts (e.g., neutropenia): reduced white blood cells increasing infection risk.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia or leukopenia: markedly low white blood cell counts.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Peripheral neuropathy: nerve damage causing tingling or numbness.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor appropriately.

  • Pregnancy risk: drug is contraindicated in pregnancy due to teratogenic potential; ensure effective contraception.
  • Thromboembolic risk: assess patient history and consider prophylactic anticoagulation.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Renal impairment: adjust use in patients with severe renal dysfunction.
  • Drug interactions: avoid concomitant use with strong CYP inducers without supervision.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of thrombosis when combined without prophylaxis.
  • Immunosuppressants (e.g., cyclosporine): may enhance immunosuppression.
  • Live vaccines: risk of infection; avoid concurrent administration.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may modestly increase plasma levels.
  • P‑glycoprotein inhibitors (e.g., verapamil): could affect clearance.
  • Hormonal contraceptives: may have reduced efficacy; advise additional contraception.

Frequently Asked Questions

Lenalidomide Sandoz 15 Mg Hard Capsules are prescribed for the treatment of certain hematologic cancers, specifically multiple myeloma, myelodysplastic syndromes that carry a del(5q) chromosomal abnormality, and mantle cell lymphoma. The medication works as part of a broader therapeutic regimen aimed at controlling disease progression and improving patient outcomes.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This interaction leads to the targeted degradation of transcription factors Ikaros and Aiolos, which modulates cytokine production, suppresses angiogenesis, and enhances immune‑mediated tumor cell killing, thereby inhibiting the growth of malignant cells.

The prescribed dose of Lenalidomide Sandoz 15 Mg Hard Capsules is individualized by the treating physician. Factors influencing the dose include the specific indication, disease stage, patient’s renal function, prior therapies, and overall health status. The prescriber will set the appropriate dosing schedule and may adjust it based on clinical response and laboratory monitoring.

Lenalidomide is classified as having an unknown pregnancy category and is considered teratogenic. It should not be used by pregnant women, and effective contraception is required for both male and female patients of reproductive potential. Limited data exist for breastfeeding, so the drug is generally avoided during lactation unless the benefits outweigh the potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lenalidomide Sandoz 15 Mg Hard Capsules. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug (IMiD) class, sharing a mechanism with thalidomide and pomalidomide. Compared with thalidomide, lenalidomide generally offers greater potency with a more favorable side‑effect profile, especially regarding neuropathy. Pomalidomide is a newer IMiD used after lenalidomide failure and may provide additional efficacy but can have similar hematologic risks.

Store Lenalidomide Sandoz 15 Mg Hard Capsules at ambient temperature below 25 °C. Keep the capsules in their original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

The capsules are taken orally, usually once daily, and should be swallowed whole with water. They may be taken with or without food, depending on the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

Key serious risks include teratogenicity (birth defects), thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe cytopenias (especially neutropenia and thrombocytopenia), and the potential development of secondary primary malignancies. Prompt reporting of symptoms like unexplained bruising, shortness of breath, or signs of infection is essential.

Lenalidomide should not be used by pregnant women or individuals planning to become pregnant without effective contraception. Patients with known hypersensitivity to lenalidomide or any capsule excipients, those with uncontrolled infections, or individuals with severe renal impairment without dose adjustment should avoid the medication. Final eligibility is determined by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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