Product image of Lenalidomide Stada (Lenalidomide) supplied by GNH India

Lenalidomide Stada

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Stada (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Stada, is an immunomodulatory imide drug (IMiD) presented as an oral formulation for oral use. It treats multiple myeloma and myelodysplastic syndromes with del(5q) in adult patients.

GNH India supplies Lenalidomide Stada as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Lenalidomide is indicated for hematologic malignancies and related disorders.

  • Multiple myeloma: improves progression‑free survival and overall response when used in approved combination regimens.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and improves peripheral blood counts.
  • Follicular lymphoma (relapsed/refractory): used to achieve disease control in patients who have failed prior therapy.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects that inhibit proliferation of malignant plasma cells and restore immune surveillance.

Side Effects

Lenalidomide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue: persistent tiredness reported by many patients.
  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: lowered platelet levels leading to easy bruising.
  • Diarrhea: loose stools that may require supportive care.
  • Rash: mild skin eruptions or itching.
  • Constipation: difficulty passing stool.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: profound drop in neutrophils with fever.
  • Severe thrombocytopenia: risk of serious bleeding.
  • Secondary primary malignancies: emergence of new cancers.
  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate discontinuation.
  • Tumor lysis syndrome: rapid tumor breakdown causing metabolic disturbances.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate baseline health status and monitor patients regularly.

  • Monitor blood counts: perform complete blood count weekly during the first cycles.
  • Assess thromboembolic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use effective contraception: both male and female patients must avoid pregnancy.
  • Pregnancy: contraindicated or unknown safety; avoid use during pregnancy and lactation.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin, DOACs): increased risk of thromboembolic events.
  • Live vaccines: heightened risk of infection due to immunomodulation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase drug levels.
  • Immunosuppressants (e.g., cyclosporine, tacrolimus): additive immunosuppression.
  • Other myelosuppressive agents (e.g., chemotherapy, azacitidine): enhanced bone‑marrow suppression.

Frequently Asked Questions

Lenalidomide Stada is prescribed for adult patients with multiple myeloma and for myelodysplastic syndromes that carry the del(5q) chromosomal abnormality. In some regions it is also approved for relapsed or refractory follicular lymphoma. The drug works as part of a broader treatment plan defined by the treating oncologist.

Lenalidomide binds to cereblon, a component of the CRL4CRBN E3 ubiquitin ligase complex. This binding changes the complex’s substrate specificity, leading to the degradation of transcription factors Ikaros and Aiolos. The result is reduced tumor cell proliferation, inhibition of angiogenesis, and enhanced immune‑mediated tumor cell killing.

The specific dose of Lenalidomide Stada is determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Dosing regimens can vary widely, and the prescriber will tailor the schedule to achieve the best therapeutic outcome while minimizing risk.

Safety data for lenalidomide in pregnancy and lactation are limited, and the drug is generally considered contraindicated for pregnant or nursing women. Women of childbearing potential should use effective contraception during treatment and for a defined period after the last dose, as advised by their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lenalidomide belongs to the immunomodulatory imide drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration convenience and can be combined with dexamethasone or other agents. Clinical trials have shown comparable or additive efficacy, but the choice of therapy depends on individual patient factors and prior treatment history.

Lenalidomide Stada should be stored at temperatures below 25 °C (77 °F). Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use. Do not store in a refrigerator or freezer unless the label specifically indicates otherwise.

Lenalidomide Stada is taken orally, usually with or without food, as directed by the prescribing physician. The tablets are swallowed whole with a full glass of water. Patients should follow the dosing schedule provided on the prescription label and attend regular monitoring appointments.

The most serious risks include severe neutropenia and thrombocytopenia, which can lead to infections or bleeding, and an increased incidence of venous thromboembolism. Rare but critical adverse events such as secondary primary malignancies, Stevens‑Johnson syndrome, and tumor lysis syndrome also require immediate medical attention.

Patients with known hypersensitivity to lenalidomide or any component of the formulation should avoid the drug. It is also contraindicated in individuals who are pregnant, planning to become pregnant without effective contraception, or who have uncontrolled infections or severe organ dysfunction that would increase the risk of serious adverse events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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