Product image of Lenalidomide Sun Pharma (Lenalidomide) supplied by GNH India

Lenalidomide Sun Pharma

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Sun Pharma (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Sun Pharma, is an immunomodulatory agent presented as an oral dosage form for oral use. It treats multiple myeloma and myelodysplastic syndromes in adult patients.

GNH India supplies Lenalidomide Sun Pharma as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sun Pharma Uk Limited

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Indications & Clinical Uses

  • Lenalidomide is employed in hematologic malignancies and related bone‑marrow disorders.
  • Multiple myeloma: improves progression‑free survival and overall response rates.
  • Myelodysplastic syndromes: reduces transfusion dependence and improves peripheral blood counts.

How It Works

  • Lenalidomide modulates the immune system by enhancing T‑cell and natural‑killer cell activity, inhibits angiogenesis, and induces apoptosis of malignant plasma cells. It binds to cereblon, a component of the E3 ubiquitin ligase complex, altering substrate degradation and affecting cytokine production and cell‑cycle regulation.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Neutropenia: reduced neutrophil count.
  • Thrombocytopenia: lowered platelet levels.
  • Fatigue: persistent tiredness.
  • Nausea: upset stomach and vomiting.
  • Diarrhea: loose stools.
  • Rash: skin irritation or redness.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in veins.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatic failure: significant liver dysfunction.
  • Severe infections: opportunistic or bacterial infections.

Precautions & Warnings

Before initiating therapy with Lenalidomide, several precautions should be observed.

  • Monitor blood counts: perform regular CBC to detect neutropenia or thrombocytopenia.
  • Assess thrombotic risk: evaluate history of clotting disorders and consider prophylactic anticoagulation.
  • Evaluate renal and hepatic function: adjust use if significant impairment is present.
  • Avoid use in pregnancy: drug is contraindicated; ensure effective contraception for women of childbearing potential.
  • Discontinue if severe reactions occur: stop treatment upon signs of serious skin reactions or organ toxicity.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase lenalidomide plasma levels, raising toxicity risk.
  • Thalidomide: combined use heightens peripheral neuropathy and thrombotic risk.
  • Anticoagulants (e.g., warfarin): may enhance bleeding tendency.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): reduce lenalidomide exposure, potentially decreasing effectiveness.
  • NSAIDs: may exacerbate thrombocytopenia and increase bleeding risk.

Frequently Asked Questions

Lenalidomide Sun Pharma is indicated for the treatment of adult patients with multiple myeloma and for certain myelodysplastic syndromes, particularly those with deletion of chromosome 5q. It is used as part of a therapeutic regimen to control disease progression and improve blood cell counts.

Lenalidomide exerts its effect by binding to the cereblon protein, part of an E3 ubiquitin ligase complex. This interaction modifies the degradation of specific transcription factors, leading to enhanced immune cell activity, inhibition of new blood‑vessel formation, and induction of programmed cell death in malignant plasma cells.

The dosage of Lenalidomide Sun Pharma is individualized by the prescribing clinician based on the specific indication, disease severity, renal function, and patient tolerance. Only a qualified healthcare professional should determine the appropriate dose and schedule.

Lenalidomide is contraindicated in pregnancy because it can cause fetal harm. Women of childbearing potential must use effective contraception during treatment and for a defined period after the last dose. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Lenalidomide belongs to the immunomodulatory drug class and differs from proteasome inhibitors or monoclonal antibodies by primarily enhancing immune response and inhibiting angiogenesis. Clinical studies show it can be effective as a single agent or in combination regimens, offering an alternative mechanism of action compared with other standard myeloma therapies.

Lenalidomide Sun Pharma should be stored at temperatures below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure the packaging remains sealed until use to maintain stability.

Lenalidomide Sun Pharma is taken orally, usually with or without food, as directed by the prescribing physician. The tablets (or capsules, depending on the supplied form) should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include the development of venous thromboembolism, severe skin reactions such as Stevens‑Johnson syndrome, secondary primary malignancies, significant liver injury, and life‑threatening infections. Patients should be monitored closely for these events, and therapy should be stopped immediately if any serious adverse reaction occurs.

Lenalidomide Sun Pharma should not be used by individuals who are pregnant, have uncontrolled infections, have a known hypersensitivity to lenalidomide or any excipients, or have severe renal or hepatic impairment without appropriate dose adjustment. The drug is also contraindicated in patients with a history of thromboembolic events unless prophylactic anticoagulation is in place.

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GNH India Pharmaceuticals Limited

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Last updated:

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