Product image of Lenalidomide Teva (Lenalidomide) supplied by GNH India

Lenalidomide Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Teva, is an Immunomodulatory agent presented as a tablet (strength not specified) for oral use. It is used to treat certain blood cancers, including multiple myeloma and myelodysplastic syndromes, in adult patients.

GNH India supplies Lenalidomide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Lenalidomide is employed in the management of hematologic malignancies and related disorders.
  • Multiple Myeloma: improves progression‑free survival and overall response rates.
  • Myelodysplastic Syndromes: reduces transfusion dependence and delays disease progression.
  • Relapsed or Refractory Multiple Myeloma: provides therapeutic benefit as a maintenance or salvage option.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, modulating cytokine production, enhancing T‑cell and NK‑cell activity, and inhibiting angiogenesis, collectively exerting antineoplastic effects.

Side Effects

Lenalidomide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue or weakness
  • Neutropenia (low neutrophil count)
  • Thrombocytopenia (low platelet count)
  • Diarrhea or constipation
  • Nausea and vomiting
  • Rash or pruritus

Serious or Rare Side Effects

  • Venous thromboembolism (deep vein thrombosis, pulmonary embolism)
  • Severe infections (pneumonia, sepsis)
  • Secondary primary malignancies
  • Hepatic dysfunction or failure
  • Severe cutaneous reactions (Stevens‑Johnson syndrome)

Precautions & Warnings

  • Before initiating therapy, clinicians should assess baseline parameters and monitor patients regularly.
  • Monitor Blood Counts: perform complete blood count weekly during the first cycles.
  • Assess Thrombotic Risk: evaluate history of clotting disorders and consider prophylactic anticoagulation.
  • Evaluate Renal Function: adjust dosing in patients with impaired clearance.
  • Contraception Counseling: advise both male and female patients of teratogenic risk and use effective contraception.
  • Avoid Live Vaccines: do not administer live attenuated vaccines during treatment.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine) – may reduce drug exposure.
  • Anticoagulants (e.g., warfarin) – increased risk of bleeding.
  • Live vaccines – heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole) – may modestly increase exposure.
  • NSAIDs – may exacerbate thrombocytopenia.
  • Digoxin – monitor serum levels as lenalidomide may affect renal clearance.

Frequently Asked Questions

Lenalidomide Teva is indicated for the treatment of multiple myeloma and myelodysplastic syndromes in adult patients. It may be used in both newly diagnosed and relapsed or refractory settings, depending on the prescribing clinician’s assessment.

Lenalidomide binds to the cereblon protein within the CRL4‑CRBN ubiquitin ligase complex, leading to the degradation of transcription factors Ikaros and Aiolos. This action modulates the immune response, enhances T‑cell and natural‑killer cell activity, and inhibits angiogenesis, contributing to its antineoplastic activity.

The dose of Lenalidomide Teva is individualized by the prescribing physician based on the specific indication, disease stage, renal function, and patient tolerance. Only a qualified healthcare professional should determine the appropriate regimen.

Lenalidomide is classified as potentially teratogenic. It should not be used by pregnant women or women who may become pregnant without effective contraception. Breastfeeding is not recommended while on therapy, and patients should discuss contraceptive options with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It is often combined with dexamethasone or used as maintenance therapy, providing a complementary approach that can improve progression‑free survival when used according to clinical guidelines.

Store Lenalidomide Teva at temperatures below 25 °C in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight to maintain stability and potency.

Lenalidomide Teva is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious risks include venous thromboembolism, severe neutropenia or thrombocytopenia leading to infection or bleeding, secondary primary malignancies, and significant hepatic dysfunction. Patients should be monitored closely for these events throughout therapy.

Lenalidomide Teva is contraindicated in patients with known hypersensitivity to lenalidomide or any component of the formulation. It should also be avoided in individuals who are pregnant, not using effective contraception, or have uncontrolled infections without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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