Product image of Lenalidomide Teva (Lenalidomide) supplied by GNH India

Lenalidomide Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Teva, is an immunomodulatory agent presented as a tablet for oral use. It is indicated for the treatment of multiple myeloma and myelodysplastic syndromes in adult patients. It works by modulating the immune system and inhibiting angiogenesis, providing clinical benefit in these hematologic cancers.

GNH India supplies Lenalidomide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and offers reliable logistics to support treatment programs across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies and related bone marrow disorders, targeting disease pathways that involve abnormal plasma cells and dysplastic hematopoiesis.

  • Multiple Myeloma: improves progression‑free survival and overall response rates in relapsed or newly diagnosed patients.
  • Multiple Myeloma (maintenance): prolongs remission duration after initial therapy.
  • Myelodysplastic Syndromes with del(5q): reduces transfusion dependence and improves blood counts.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), resulting in reduced proliferation of malignant plasma cells, enhanced immune‑mediated tumor cell killing, and inhibition of angiogenic factors. The combined immunomodulatory and anti‑angiogenic actions contribute to its antineoplastic effect.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Neutropenia
  • Fatigue
  • Diarrhea
  • Rash

Serious or Rare Side Effects

  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)
  • Severe infections, including opportunistic pathogens
  • Second primary malignancies

Precautions & Warnings

Patients receiving Lenalidomide should be monitored closely for safety concerns.

  • Blood count monitoring: perform complete blood counts regularly to detect cytopenias.
  • Thromboembolism risk assessment: evaluate patient history and consider prophylactic anticoagulation.
  • Pregnancy avoidance: contraindicated in pregnancy; ensure effective contraception.
  • Renal and hepatic function: adjust use based on organ function assessments.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with several medicines; awareness of major and moderate interactions helps optimize safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase lenalidomide exposure.
  • Anticoagulants (warfarin): heightened risk of bleeding.
  • Live vaccines: risk of infection due to immunosuppression.
  • Pregnancy‑category teratogenic agents: additive teratogenic risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of renal toxicity.
  • Antihypertensives (e.g., ACE inhibitors): monitor blood pressure.

Frequently Asked Questions

Lenalidomide Teva is prescribed for adult patients with multiple myeloma and for those with myelodysplastic syndromes that have a deletion of chromosome 5q. In these conditions it helps control disease progression, improve blood counts and reduce the need for transfusions.

Lenalidomide binds to the cereblon protein within the CRL4‑E3 ubiquitin ligase complex, causing selective degradation of the transcription factors Ikaros and Aiolos. This action suppresses malignant plasma‑cell growth, enhances immune‑mediated tumor cell killing, and blocks new blood‑vessel formation that supports cancer.

The specific dose of Lenalidomide Teva is determined by the treating physician based on the patient’s diagnosis, disease stage, renal function and other clinical factors. Prescribers follow approved labeling and clinical guidelines to set the appropriate regimen.

Lenalidomide is classified as a teratogenic drug and is contraindicated during pregnancy. Women of child‑bearing potential must use effective contraception before, during and after treatment. Safety during breastfeeding has not been established, so nursing is generally discouraged while on therapy.

To place an order, submit an enquiry on the Lenalidomide Teva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide and thalidomide belong to the same immunomodulatory class, but lenalidomide is generally more potent, has a more favorable safety profile, and is less likely to cause peripheral neuropathy. Both target cereblon, yet lenalidomide’s broader anti‑angiogenic and immune‑activating effects make it a preferred option in many treatment protocols.

Lenalidomide Teva tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Protect the product from excess moisture, heat and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.

Lenalidomide Teva is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed. Treatment cycles and duration are defined by the treating physician.

The most serious risks include severe neutropenia or leukopenia that can predispose to infection, thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, and the potential for second primary cancers. Patients should be monitored regularly for blood‑count changes and signs of clotting.

Lenalidomide Teva should not be used by individuals who are pregnant, have uncontrolled infections, or have a known hypersensitivity to lenalidomide or any of its excipients. Caution is also advised for patients with severe renal or hepatic impairment, and the drug is avoided in those receiving live vaccines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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