Product image of Lenalidomide Wockhardt Uk (Lenalidomide) supplied by GNH India

Lenalidomide Wockhardt Uk

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomide Wockhardt Uk (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomide Wockhardt Uk, is an immunomodulatory agent presented as a tablet for oral use. It treats multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomide Wockhardt Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Wockhardt Uk Ltd

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory antineoplastic agent used in hematologic malignancies.

  • Multiple Myeloma: improves progression‑free survival and overall response rates.
  • Myelodysplastic Syndromes: reduces transfusion dependence and improves peripheral blood counts.
  • Mantle Cell Lymphoma: induces tumor regression and prolongs remission periods.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This triggers degradation of transcription factors Ikaros and Aiolos, producing anti‑angiogenic, immunomodulatory, and anti‑proliferative actions that suppress malignant plasma cells and related hematologic cancer cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, some of which are frequent and others that are uncommon but potentially serious.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: lowered platelet count leading to bleeding tendencies.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require supportive care.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Secondary primary malignancies: emergence of new cancers.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Lenalidomide requires careful monitoring and adherence to safety measures.

  • Pregnancy Risk: avoid use during pregnancy; effective contraception is required.
  • Thromboembolic Prophylaxis: consider anticoagulation in high‑risk patients.
  • Hematologic Monitoring: regular blood counts to detect neutropenia or thrombocytopenia.
  • Renal Impairment: dose adjustment may be needed in reduced kidney function.
  • Drug Interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with several drug classes, requiring clinical vigilance.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lenalidomide exposure.
  • Anticoagulants: increased risk of bleeding when combined with thrombocytopenia.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants: may enhance infection risk.
  • P-glycoprotein substrates: potential alteration of plasma levels.
  • NSAIDs: may exacerbate gastrointestinal irritation.
  • Vaccines: live vaccines should be avoided due to immunomodulation.

Frequently Asked Questions

Lenalidomide Wockhardt Uk is indicated for the treatment of multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma in adult patients. It is used as part of an antineoplastic regimen to improve disease control and extend survival in these hematologic cancers.

Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, changing its activity. This leads to the degradation of specific transcription factors, resulting in anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that suppress malignant plasma cells and other cancerous blood cells.

The dosage of Lenalidomide Wockhardt Uk is determined by the prescribing clinician based on the specific indication, patient characteristics and treatment protocol. The prescriber sets the exact dose and schedule according to approved guidelines and individual patient needs.

Lenalidomide is classified as potentially harmful to a developing fetus and is contraindicated in pregnancy. Women of childbearing potential must use effective contraception. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while on therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide is a derivative of thalidomide with enhanced immunomodulatory activity and a more favorable safety profile. It generally offers greater efficacy in multiple myeloma and reduced incidence of peripheral neuropathy compared with thalidomide, though both require careful monitoring for hematologic toxicity.

Lenalidomide tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lenalidomide Wockhardt Uk is taken orally as a tablet, usually once daily on a prescribed schedule. It is typically swallowed with water and may be taken with or without food, depending on the prescriber’s instructions.

The most serious risks include severe neutropenia and thrombocytopenia, which can lead to infections or bleeding, and the potential for venous thromboembolism. Rarely, secondary primary malignancies may develop. Patients should be monitored closely for these events.

Lenalidomide is contraindicated in patients with known hypersensitivity to the drug or its excipients, in pregnant women, and in individuals who cannot adhere to required contraception. Caution is also advised for patients with severe renal impairment or uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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