Product image of Lenaster (Hydrocortisone Sodium Phosphate) supplied by GNH India

Lenaster

Active Ingredient:
Hydrocortisone Sodium Phosphate
Origin:
EU

Lenaster (Hydrocortisone Sodium Phosphate)

Hydrocortisone Sodium Phosphate, the active ingredient in Lenaster, is a corticosteroid presented as a sterile ophthalmic solution for ocular use. It reduces inflammation in the eye and is employed in the management of postoperative inflammation, allergic conjunctivitis, and other inflammatory ocular conditions.

GNH India supplies Lenaster as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

  • Lenaster (hydrocortisone sodium phosphate) is used to treat inflammatory conditions of the eye.
  • Post‑operative ocular inflammation: reduces swelling, pain and redness after eye surgery.
  • Allergic conjunctivitis: alleviates itching, tearing and hyperemia caused by allergens.
  • Anterior uveitis: suppresses intra‑ocular inflammation and prevents tissue damage.
  • Corneal inflammation (keratitis): diminishes edema and promotes healing of the corneal surface.

How It Works

  • Hydrocortisone sodium phosphate acts as a glucocorticoid receptor agonist. After penetrating ocular tissues, it binds intracellular glucocorticoid receptors, translocates to the nucleus and modulates gene transcription. This inhibits the synthesis of pro‑inflammatory cytokines, prostaglandins, leukotrienes and other mediators, thereby decreasing vascular permeability, leukocyte migration and edema in the eye.

Side Effects

Common Side Effects

  • Transient ocular irritation or burning sensation.
  • Increased intra‑ocular pressure.
  • Blurred vision.
  • Tearing or watery eyes.
  • Mild conjunctival hyperemia.
  • Foreign‑body sensation.

Serious or Rare Side Effects

  • Secondary ocular infection.
  • Cataract formation with prolonged use.
  • Glaucoma due to sustained pressure rise.
  • Delayed wound healing after surgery.
  • Severe allergic reaction (e.g., angio‑edema).
  • Corneal ulceration or perforation.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor intra‑ocular pressure: check IOP regularly during treatment.
  • Assess for active ocular infection: avoid use if infection is present.
  • Use the lowest effective duration: limit exposure to reduce risk of cataract or glaucoma.
  • Caution in patients with known steroid sensitivity: watch for hypersensitivity reactions.
  • Avoid concurrent use of other potent ocular steroids unless directed.
  • Store at ambient temperature: keep below 25°C, in the original container, protected from moisture and light.

Avoid Interactions

Hydrocortisone sodium phosphate may interact with other ophthalmic agents.

Major Interactions (Avoid)

  • Systemic corticosteroids: additive systemic glucocorticoid effects.
  • Anticholinergic eye drops: may diminish anti‑inflammatory efficacy.
  • Monoamine oxidase inhibitors: rare risk of hypertensive response.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: increased risk of corneal toxicity.
  • Topical antibiotics: possible reduction in antimicrobial activity; monitor infection control.

Frequently Asked Questions

Lenaster is an ophthalmic preparation containing hydrocortisone sodium phosphate. It is prescribed to reduce inflammation and swelling in the eye following surgery, to treat allergic conjunctivitis, and to manage other inflammatory ocular conditions such as anterior uveitis or keratitis.

The active ingredient binds to intracellular glucocorticoid receptors in ocular tissues. This complex alters gene expression, suppressing the production of inflammatory cytokines, prostaglandins, and leukotrienes. The result is decreased vascular permeability, reduced leukocyte infiltration, and overall mitigation of ocular inflammation.

The specific dosing regimen for Lenaster is determined by the prescribing eye‑care professional based on the condition being treated, severity, and patient response. The prescriber will provide detailed instructions on the number of drops, frequency, and duration of therapy.

Safety data for hydrocortisone sodium phosphate in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers will evaluate individual circumstances before prescribing.

To request Lenaster, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lenaster delivers hydrocortisone sodium phosphate, a relatively short‑acting corticosteroid with a favorable safety profile for short‑term use. Compared with more potent agents such as dexamethasone or prednisolone acetate, it may have a lower risk of intra‑ocular pressure rise but may require more frequent dosing for equivalent anti‑inflammatory effect.

Lenaster should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight and extreme temperature fluctuations. Do not freeze the solution, and discard any vial that appears cloudy or contaminated.

Lenaster is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops without touching the tip to the eye or surrounding structures. Follow the prescriber’s dosing schedule precisely.

Serious risks include a sustained increase in intra‑ocular pressure leading to glaucoma, development of cataracts with prolonged use, secondary ocular infections, and rare severe allergic reactions such as angio‑edema. Patients should report any sudden vision changes, eye pain, or signs of infection promptly.

Lenaster should be avoided in individuals with known hypersensitivity to hydrocortisone sodium phosphate or any component of the formulation, active ocular infections, or uncontrolled glaucoma. It is also contraindicated in patients receiving other potent ocular steroids unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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