Product image of Lenaxolan (Doxazosin Mesilate) supplied by GNH India

Lenaxolan

Active Ingredient:
Doxazosin Mesilate
Origin:
EU

Lenaxolan (Doxazosin Mesilate)

Doxazosin mesilate, the active ingredient in Lenaxolan, is a alpha‑1 adrenergic blocker presented as an oral tablet for oral use. It is used to treat hypertension and benign prostatic hyperplasia in adult patients.

GNH India supplies Lenaxolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lanova Farmaceutici S.R.L.

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Indications & Clinical Uses

Doxazosin mesilate acts on the vascular smooth‑muscle and prostatic tissue to lower blood pressure and improve urinary flow.

  • Hypertension: helps lower systolic and diastolic blood pressure in essential or secondary hypertension.
  • Benign prostatic hyperplasia: reduces prostate smooth‑muscle tone, easing urinary obstruction and frequency.
  • Lower urinary tract symptoms: improves urinary flow and reduces nocturia associated with BPH.

How It Works

  • Doxazosin mesilate selectively and reversibly blocks alpha‑1 adrenergic receptors on vascular smooth muscle and prostatic stromal tissue. This antagonism prevents norepinephrine‑induced vasoconstriction, leading to vasodilation and reduced peripheral vascular resistance, while also relaxing prostatic smooth muscle to improve urinary outflow.

Side Effects

Doxazosin mesilate may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue or tiredness.
  • Nasal congestion.
  • Swelling of the ankles or feet.
  • Nausea.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Heart palpitations or arrhythmia.
  • Priapism (prolonged erection).
  • Liver function abnormalities.
  • Severe allergic reactions such as rash, itching, or swelling.
  • Persistent cough or bronchospasm.

Precautions & Warnings

Before initiating therapy with doxazosin mesilate, several safety considerations should be reviewed.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Cardiovascular disease: use cautiously in patients with coronary artery disease or recent myocardial infarction.
  • Liver impairment: dose may need adjustment in moderate to severe hepatic dysfunction.
  • Concomitant antihypertensives: monitor for additive blood‑pressure lowering effects.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Doxazosin mesilate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause profound hypotension.
  • Other alpha‑blockers (e.g., prazosin, terazosin): increase risk of severe blood‑pressure drop.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise plasma concentrations.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance orthostatic hypotension; monitor electrolytes.

  • Antihypertensive agents (beta‑blockers, ACE inhibitors): additive BP‑lowering effect.
  • NSAIDs: may blunt antihypertensive response.
  • Lithium: possible increase in lithium levels; monitor renal function.

Frequently Asked Questions

Lenaxolan contains doxazosin mesilate, which is prescribed to manage high blood pressure (hypertension) and to relieve urinary symptoms caused by benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and prostate smooth muscle, helping to lower blood pressure and improve urine flow.

Doxazosin mesilate selectively blocks alpha‑1 adrenergic receptors on vascular smooth muscle and prostatic tissue. This blockade prevents norepinephrine‑mediated contraction, causing blood vessels to dilate and reducing peripheral resistance, while also relaxing the prostate to ease urinary obstruction.

The specific dose of Lenaxolan is determined by the prescribing healthcare professional based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety data for doxazosin mesilate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Lenaxolan product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lenaxolan (doxazosin) belongs to the alpha‑1 blocker class, which lowers blood pressure by vasodilation. Compared with ACE inhibitors, beta‑blockers, or calcium‑channel blockers, it may be chosen for patients who also have BPH symptoms, as it simultaneously improves urinary flow. Choice of therapy depends on individual patient profiles and comorbidities.

Store Lenaxolan at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight. Do not store in a refrigerator or freezer unless otherwise directed by the manufacturer.

Lenaxolan is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water and avoid crushing or chewing unless the formulation specifically allows it.

Serious adverse events may include severe hypotension, syncope, heart rhythm disturbances, priapism, and rare liver function abnormalities. Patients should seek immediate medical attention if they experience fainting, chest pain, prolonged erection, or signs of an allergic reaction such as swelling or difficulty breathing.

Lenaxolan is contraindicated in patients with known hypersensitivity to doxazosin or any component of the formulation. Caution is advised for individuals with severe liver disease, uncontrolled heart failure, or those taking medications that may cause dangerous blood‑pressure drops, such as phosphodiesterase‑5 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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