Product image of Lencya (Ulipristal Acetate) supplied by GNH India

Lencya

Active Ingredient:
Ulipristal Acetate
Origin:
EU

Lencya (Ulipristal Acetate)

Ulipristal acetate, the active ingredient in Lencya, is a selective progesterone receptor modulator presented as an oral tablet for systemic use. It is employed to prevent pregnancy after unprotected intercourse and to manage symptomatic uterine fibroids in adult women.

GNH India supplies Lencya as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution.

Manufacturer / TM Owner

Sandoz Gmbh

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Indications & Clinical Uses

Lencya (ulipristal acetate) acts as a selective progesterone receptor modulator and is used in reproductive health and gynecologic conditions.

  • Emergency contraception: when administered up to five days after unprotected sexual intercourse, it can inhibit or delay ovulation, thereby reducing the risk of pregnancy in women of reproductive age.
  • Uterine fibroids: in premenopausal women, it can be used to shrink fibroid tissue and alleviate heavy menstrual bleeding, offering a non‑surgical therapeutic option.

How It Works

  • Ulipristal acetate binds to progesterone receptors with high affinity, acting as a selective progesterone receptor modulator. By blocking receptor activation, it interferes with the progesterone‑dependent signaling required for follicular rupture, thereby inhibiting or delaying ovulation. In uterine fibroid tissue, modulation of progesterone pathways reduces cell proliferation and promotes apoptosis, contributing to fibroid size reduction.

Side Effects

Ulipristal acetate may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Abdominal pain
  • Fatigue
  • Menstrual irregularities

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Liver enzyme elevation or hepatitis
  • Persistent or worsening abdominal pain suggesting possible uterine complications

Precautions & Warnings

When prescribing Lencya, clinicians should consider several precautionary measures to ensure safe use.

  • Pregnancy contraindication: avoid use in confirmed or suspected pregnancy.
  • Liver disease: assess hepatic function before initiating therapy.
  • Concomitant hormonal contraception: do not rely on Lencya as a regular contraceptive method.
  • Known hypersensitivity: discontinue if allergic reactions occur.
  • Drug interactions: review concomitant medications that may affect efficacy.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Ulipristal acetate can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, St John’s wort): may markedly reduce drug levels.
  • Combined hormonal contraceptives: may decrease efficacy of both agents.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may modestly lower plasma concentrations.
  • Antifungal agents (e.g., ketoconazole, itraconazole): may increase exposure, requiring monitoring.
  • Antiretrovirals (e.g., efavirenz): potential interaction affecting metabolism.

Frequently Asked Questions

Lencya contains ulipristal acetate and is prescribed for two primary purposes: as an emergency contraceptive to prevent pregnancy after unprotected sexual contact, and as a medical therapy to reduce the size of uterine fibroids and control associated heavy menstrual bleeding in premenopausal women.

Ulipristal acetate acts as a selective progesterone receptor modulator. It binds to progesterone receptors in the ovary, blocking the hormone’s action and thereby inhibiting or delaying the release of an egg (ovulation). In fibroid tissue, the same receptor modulation reduces cell growth and promotes apoptosis, leading to shrinkage of the fibroids.

The dosage of Lencya is determined by the prescribing clinician based on the indication and patient characteristics. For emergency contraception, a single oral dose is typically prescribed, while fibroid management may involve a different regimen. Exact dosing instructions should always be obtained from a qualified healthcare professional.

Lencya is contraindicated in confirmed or suspected pregnancy because its mechanism interferes with normal hormonal processes. Limited data are available on its excretion in breast milk, and the product is generally not recommended for breastfeeding mothers unless the benefits outweigh potential risks as assessed by a physician.

To order Lencya, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The most common alternative for emergency contraception is levonorgestrel, a progestin that must be taken within 72 hours of intercourse. Ulipristal acetate (Lencya) remains effective up to five days and works by directly modulating progesterone receptors, offering a longer window of efficacy and a different mechanism compared with levonorgestrel.

Lencya tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. No refrigeration is required.

Lencya is taken orally as a tablet. The tablet should be swallowed whole with a glass of water. It is usually taken as a single dose for emergency contraception; dosing for fibroid treatment follows the regimen prescribed by the treating physician.

The most serious adverse reactions associated with Lencya include severe allergic responses such as anaphylaxis, significant liver injury indicated by elevated enzymes or hepatitis, and persistent abdominal pain that could signal uterine complications. Patients should seek immediate medical attention if they experience any of these symptoms.

Lencya should not be used by women who are already pregnant, have a known hypersensitivity to ulipristal acetate or any excipients, have severe liver disease, or who are relying on it as a regular contraceptive method. Individuals with uncontrolled hormonal disorders should also discuss suitability with their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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