Product image of Lendorm (Brotizolam) supplied by GNH India

Lendorm

Active Ingredient:
Brotizolam
Origin:
EU

Lendorm (Brotizolam)

Brotizolam, the active ingredient in Lendorm, is a benzodiazepine presented as a tablet for oral use. It is indicated for the short‑term treatment of insomnia in adults.

GNH India supplies Lendorm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Boehringer Ingelheim Rcv Gmbh & Co Kg

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Indications & Clinical Uses

Brotizolam acts on the central nervous system to facilitate sleep in patients with insomnia.

  • Insomnia (sleep initiation): helps patients fall asleep more quickly.
  • Insomnia (sleep maintenance): reduces the number of nighttime awakenings.
  • Insomnia associated with anxiety: promotes restful sleep despite underlying anxiety.

How It Works

  • Brotizolam binds to the benzodiazepine site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the inhibitory effect of gamma‑aminobutyric acid (GABA), increasing chloride ion influx and hyperpolarising neuronal membranes, which results in sedative, hypnotic, anxiolytic, and muscle‑relaxant effects.

Side Effects

Brotizolam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during the day.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Headache: mild to moderate pain in the head.
  • Fatigue: reduced energy and motivation.
  • Amnesia: difficulty recalling events after taking the medication.
  • Muscle weakness: reduced strength in limbs.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing, especially with other depressants.
  • Dependence or withdrawal syndrome: difficulty stopping the drug after prolonged use.
  • Severe allergic reactions: rash, swelling, or difficulty breathing.
  • Paradoxical reactions: increased agitation, aggression, or anxiety.
  • Suicidal thoughts: emergence of depressive or suicidal ideation.
  • Depression: worsening mood or depressive symptoms.

Precautions & Warnings

Before prescribing Brotizolam, clinicians should consider several safety factors.

  • Assess renal and hepatic function: adjust use if impairment is present.
  • Avoid abrupt discontinuation: taper the dose to prevent withdrawal.
  • Use caution in elderly patients: increased sensitivity to sedative effects.
  • Advise against operating machinery or driving: impairment may persist.
  • Contraindicated in patients with known hypersensitivity to benzodiazepines.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Brotizolam can interact with other substances that affect the central nervous system or its metabolism.

Major Interactions (Avoid)

  • Alcohol: additive sedation and respiratory depression.
  • Other CNS depressants (opioids, barbiturates): heightened sedative effect.
  • CYP3A4 inhibitors (ketoconazole, erythromycin): increased plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampin, carbamazepine): reduced efficacy.
  • Antihistamines: possible enhanced drowsiness.
  • Antihypertensives: potential additive hypotensive effect.

Frequently Asked Questions

Lendorm contains the active ingredient Brotizolam, which is prescribed as a short‑term hypnotic to treat insomnia in adult patients who have difficulty falling asleep or staying asleep.

Brotizolam enhances the activity of the inhibitory neurotransmitter GABA by binding to the benzodiazepine site on the GABA‑A receptor, increasing chloride influx and producing sedative and hypnotic effects that help initiate and maintain sleep.

The appropriate dose of Lendorm is determined by the prescribing clinician based on the patient’s medical condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Brotizolam in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Lendorm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other benzodiazepine hypnotics, Brotizolam has a relatively rapid onset and short half‑life, which may reduce next‑day residual sedation. However, choice of therapy depends on individual patient factors, efficacy, safety profile and prescriber preference.

Lendorm should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Lendorm is taken orally, usually as a single dose shortly before bedtime. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include respiratory depression, especially when combined with other CNS depressants, development of dependence or withdrawal syndrome after prolonged use, and rare paradoxical reactions such as increased agitation or aggression.

Lendorm is contraindicated in patients with known hypersensitivity to Brotizolam or other benzodiazepines, in individuals with severe respiratory insufficiency, and should be used with extreme caution or avoided in the elderly, pregnant women, and patients with significant liver or kidney impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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