Product image of Lendormin (Brotizolam) supplied by GNH India

Lendormin

Active Ingredient:
Brotizolam
Origin:
EU

Lendormin (Brotizolam)

Brotizolam, the active ingredient in Lendormin, is a benzodiazepine presented as a tablet for oral use. It treats short‑term insomnia in adults.
GNH India supplies Lendormin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Boehringer Ingelheim Portugal, Lda.

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Indications & Clinical Uses

  • Brotizolam acts on the central nervous system to facilitate sleep in patients with insomnia.
  • Insomnia: short‑term treatment of difficulty falling or staying asleep
  • Sleep onset insomnia: helps initiate sleep quickly
  • Sleep maintenance insomnia: reduces nighttime awakenings

How It Works

  • Brotizolam binds to the benzodiazepine site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the inhibitory effect of GABA, increasing chloride ion influx and hyperpolarising neuronal membranes, which leads to reduced neuronal excitability and a sedative‑hypnotic effect.

Side Effects

Brotizolam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during the day
  • Dizziness: light‑headed sensation or loss of balance
  • Dry mouth: reduced salivation causing throat discomfort
  • Headache: mild to moderate pain in the head region
  • Fatigue: general lack of energy or motivation
  • Amnesia: difficulty recalling events after taking the medication

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing that may be life‑threatening
  • Dependence or withdrawal syndrome: risk of addiction with prolonged use
  • Severe allergic reaction: rash, swelling, or difficulty breathing
  • Depression or suicidal thoughts: mood changes requiring immediate medical attention
  • Seizures: rare occurrence of convulsive episodes

Precautions & Warnings

  • Before prescribing Brotizolam, clinicians should consider several safety factors.
  • Avoid alcohol: concurrent use can markedly increase sedation and respiratory depression
  • Use caution in elderly: higher susceptibility to falls and cognitive impairment
  • Do not operate machinery: impaired psychomotor performance may occur
  • Assess renal/hepatic function: dose adjustment may be needed in impairment
  • Pregnancy and lactation: consult a physician as risks are not fully established
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Brotizolam can interact with other substances that affect the central nervous system.

Major Interactions (Avoid)

  • CNS depressants (e.g., barbiturates, opioids): additive sedation and respiratory depression
  • Alcohol: potentiates sedative effects and impairs coordination
  • Antifungal agents (ketoconazole): may increase Brotizolam plasma concentrations

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (erythromycin, clarithromycin): can raise drug levels modestly
  • CYP3A4 inducers (rifampicin, carbamazepine): may reduce therapeutic effect
  • Selective serotonin reuptake inhibitors (SSRIs): may enhance central sedation

Frequently Asked Questions

Lendormin contains the benzodiazepine Brotizolam and is prescribed for the short‑term treatment of insomnia, helping patients fall asleep faster and stay asleep through the night.

Brotizolam enhances the activity of the inhibitory neurotransmitter GABA by binding to the benzodiazepine site on GABA‑A receptors, increasing chloride influx and producing a calming, sedative effect that facilitates sleep.

The exact dose of Lendormin is determined by the prescribing physician based on the patient’s age, clinical condition, and response to therapy. Dosage instructions are provided on the prescription label.

Safety of Brotizolam in pregnancy or lactation has not been fully established. Physicians should evaluate the potential benefits against risks and consider alternative treatments for pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other hypnotics such as zolpidem or temazepam, Brotizolam has a relatively rapid onset and short half‑life, which may reduce next‑day residual sedation but also carries a similar risk of dependence and withdrawal if used beyond the recommended short‑term period.

Lendormin tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep out of reach of children and do not use after the expiry date.

Lendormin is taken orally, usually shortly before bedtime. Patients should swallow the tablet whole with a glass of water and avoid taking it with or after a heavy meal that might delay absorption.

The most serious risks include respiratory depression, especially when combined with other CNS depressants, the potential for dependence and withdrawal seizures, severe allergic reactions, and emergence of depressive or suicidal thoughts.

Lendormin is contraindicated in individuals with known hypersensitivity to Brotizolam or other benzodiazepines, patients with severe respiratory insufficiency, acute narrow‑angle glaucoma, and those who are currently abusing alcohol or other sedatives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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