Product image of Lenigron (Timolol, Bimatoprost) supplied by GNH India

Lenigron

Active Ingredient:
Timolol, Bimatoprost
Origin:
EU

Lenigron (Timolol, Bimatoprost)

Timolol and Bimatoprost, the active ingredients in Lenigron, are a beta‑blocker and a prostaglandin analog presented as eye drops for ocular use. They are employed to lower intra‑ocular pressure in patients with open‑angle glaucoma and ocular hypertension.

GNH India supplies Lenigron as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

  • Lenigron, a combination of a beta‑blocker and a prostaglandin analog, is used in the management of glaucoma and ocular hypertension.
  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers intra‑ocular pressure to prevent conversion to glaucoma.
  • Pseudoexfoliative glaucoma: improves pressure control when monotherapy is insufficient.
  • Secondary open‑angle glaucoma: assists in achieving target pressure when other agents are inadequate.

How It Works

  • Timolol acts as a non‑selective beta‑adrenergic antagonist, decreasing aqueous humor production by the ciliary body. Bimatoprost, a prostaglandin F2α analog, enhances uveoscleral outflow of aqueous humor. The combined actions result in a greater reduction of intra‑ocular pressure than either component alone.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Transient blurred vision.
  • Conjunctival hyperemia (redness).
  • Itching or mild allergic reaction on the ocular surface.
  • Dry eye sensation.
  • Temporary increase in eyelash growth.

Serious or Rare Side Effects

  • Severe allergic reaction (angio‑edema, anaphylaxis).
  • Significant worsening of glaucoma or sudden loss of vision.
  • Systemic beta‑blocker effects such as bradycardia, hypotension, or bronchospasm.
  • Persistent ocular inflammation or uveitis.
  • Corneal ulceration or severe keratitis.

Precautions & Warnings

Before initiating Lenigron, clinicians should consider the following precautions:

  • Assess cardiovascular status: timolol may affect heart rate and blood pressure.
  • Screen for respiratory disease: avoid in patients with asthma or COPD.
  • Monitor intra‑ocular pressure regularly to ensure therapeutic response.
  • Avoid use in individuals with known hypersensitivity to beta‑blockers or prostaglandin analogs.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lenigron may interact with other medicines as follows:

Major Interactions (Avoid)

  • Non‑selective beta‑blocker antagonists (e.g., propranolol): additive systemic beta‑blockade.
  • Sympathomimetic agents (e.g., epinephrine eye drops): may reduce timolol efficacy.
  • Other prostaglandin analogs: increased risk of ocular hyperemia.

Moderate Interactions (Monitor Closely)

  • Carbonic anhydrase inhibitors: additive intra‑ocular pressure‑lowering effect.
  • Systemic antihypertensives: may enhance timolol's hypotensive action.
  • Topical anesthetics: may increase corneal toxicity when used together.

Frequently Asked Questions

Lenigron is prescribed for patients with open‑angle glaucoma, ocular hypertension, and certain forms of secondary glaucoma where lowering intra‑ocular pressure is essential to prevent optic nerve damage and preserve vision.

Timolol reduces the production of aqueous humor by blocking beta‑adrenergic receptors in the ciliary body, while Bimatoprost increases the outflow of fluid through the uveoscleral pathway. The dual mechanism provides a more pronounced reduction in intra‑ocular pressure than either agent alone.

The dosing regimen for Lenigron is determined by the prescribing clinician based on the patient’s intra‑ocular pressure, response to therapy, and overall ocular health. The prescriber will provide specific instructions on the number of drops and frequency.

Safety data for Lenigron in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Lenigron product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenigron combines a beta‑blocker and a prostaglandin analog, offering a two‑pronged approach to pressure reduction. Compared with monotherapy agents, the combination can achieve greater intra‑ocular pressure lowering, potentially reducing the need for multiple separate drops.

Lenigron should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contaminated.

Lenigron is applied as an ocular drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Avoid touching the tip of the bottle to the eye or any surface.

Serious risks include severe allergic reactions, significant worsening of glaucoma, systemic beta‑blocker effects such as bradycardia, hypotension, or bronchospasm, and rare ocular complications like corneal ulceration or uveitis. Patients should seek immediate medical attention if they experience these symptoms.

Lenigron is contraindicated in patients with known hypersensitivity to timolol, bimatoprost, or any component of the formulation, as well as in individuals with severe asthma, chronic obstructive pulmonary disease, or certain cardiac conditions where systemic beta‑blockade could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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