Product image of Lenitral Injectable (Glyceryl Trinitrate) supplied by GNH India

Lenitral Injectable

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Lenitral Injectable (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Lenitral Injectable, is an organic nitrate presented as an injectable solution for intravenous use. It is employed to manage acute coronary syndrome, angina pectoris, heart failure, and hypertensive emergencies in hospital settings. It provides rapid relief of myocardial ischemia and assists blood pressure control in emergency care.

GNH India supplies Lenitral Injectable as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for clinical use across multiple regions.

Manufacturer / TM Owner

Besins Healthcare France

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Indications & Clinical Uses

Lenitral Injectable (glyceryl trinitrate) acts within the cardiovascular emergency pathway to relieve myocardial ischemia and reduce cardiac workload.

  • Acute coronary syndrome: provides rapid vasodilation to improve coronary blood flow and lower myocardial oxygen demand.
  • Angina pectoris: relieves chest pain by decreasing preload and afterload.
  • Heart failure: reduces ventricular filling pressures and eases pulmonary congestion.
  • Hypertensive emergencies: lowers systemic vascular resistance for prompt blood pressure control.

How It Works

  • Glyceryl trinitrate is metabolized to nitric oxide, which activates soluble guanylate cyclase in vascular smooth muscle. This increases cyclic GMP levels, leading to relaxation of arterial and venous smooth muscle, vasodilation, reduced preload and afterload, and consequently lower myocardial oxygen consumption.

Side Effects

Common Side Effects

  • Headache: throbbing pain due to cerebral vasodilation.
  • Hypotension: transient drop in blood pressure, especially with rapid infusion.
  • Flushing: warm sensation and reddening of skin.
  • Tachycardia: compensatory increase in heart rate.
  • Dizziness or light‑headedness.
  • Nausea or vomiting.

Serious or Rare Side Effects

  • Severe hypotension leading to syncope.
  • Paradoxical myocardial ischemia.
  • Methemoglobinemia.
  • Anaphylactoid or allergic reactions.
  • Life‑threatening arrhythmias.
  • Cardiogenic shock in susceptible patients.

Precautions & Warnings

Before use, clinicians should consider the following precautions:

  • Assess blood pressure before administration: monitor for excessive hypotension.
  • Avoid concurrent use with phosphodiesterase‑5 inhibitors: risk of profound vasodilation.
  • Use with caution in severe anemia: may worsen tissue hypoxia.
  • Monitor for tolerance development: consider drug‑free intervals to maintain efficacy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Glyceryl trinitrate may interact with several drug classes.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): additive vasodilation causing severe hypotension.
  • Other nitrates (e.g., isosorbide dinitrate): risk of profound blood pressure fall.
  • Potent antihypertensives (e.g., hydralazine): may cause excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardic response to hypotension.
  • Calcium channel blockers: can enhance hypotensive effect.
  • Diuretics: may increase risk of volume depletion and orthostatic changes.

Frequently Asked Questions

Lenitral Injectable contains glyceryl trinitrate and is used in hospital settings to treat acute coronary syndrome, angina pectoris, heart failure, and hypertensive emergencies by providing rapid vasodilation and reducing cardiac workload.

Glyceryl trinitrate releases nitric oxide, which activates soluble guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of arteries and veins, lowering preload and afterload, and improving coronary blood flow.

The specific dose and infusion rate of Lenitral Injectable are determined by the prescribing clinician based on the patient’s condition, response, and institutional protocols. No fixed dosing regimen is provided here.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit justifies any potential risk, and decisions should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Lenitral Injectable is an intravenous organic nitrate, offering rapid onset of action compared with oral antianginals such as beta‑blockers or calcium‑channel blockers. Its effect is short‑acting, allowing precise titration in emergency settings, whereas oral agents provide longer‑term control.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the manufacturer’s label for any additional handling instructions.

Lenitral Injectable is given by intravenous infusion under continuous clinical monitoring. The infusion rate is adjusted according to the patient’s blood pressure, heart rate, and therapeutic response, as directed by the treating physician.

Serious risks include severe hypotension, paradoxical myocardial ischemia, methemoglobinemia, life‑threatening arrhythmias, and anaphylactoid reactions. Prompt recognition and management of these events are essential during administration.

Patients with known hypersensitivity to glyceryl trinitrate or other organic nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24‑48 hours, and individuals with severe hypotension or certain types of shock should not receive this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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