Product image of Lenizak (Tramadol Hydrochloride, Dexketoprofen) supplied by GNH India

Lenizak

Active Ingredient:
Tramadol Hydrochloride, Dexketoprofen
Origin:
EU

Lenizak (Tramadol Hydrochloride, Dexketoprofen)

Tramadol Hydrochloride and Dexketoprofen, the active ingredients in Lenizak, are an opioid analgesic and a non‑steroidal anti‑inflammatory drug presented as oral tablets for oral use. The combination is indicated for the management of moderate to severe acute pain, post‑operative pain, and musculoskeletal pain in adult patients.

GNH India supplies Lenizak as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our network ensures timely delivery, regulatory compliance, and adherence to stringent quality standards across global markets.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Lenizak, a combined opioid‑NSAID analgesic, is indicated for several acute pain conditions.

  • Moderate to severe acute pain: provides rapid analgesia by acting on central opioid receptors and reducing peripheral inflammation.
  • Post‑operative pain: lowers pain intensity after surgical procedures, supporting early mobilization and recovery.
  • Musculoskeletal pain: eases pain from injuries, sprains, or inflammatory conditions, improving functional ability.

How It Works

  • Tramadol Hydrochloride acts as a weak µ‑opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain inhibition. Dexketoprofen blocks cyclo‑oxygenase‑1 and‑2 enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation and peripheral nociceptive signaling. The complementary actions provide synergistic analgesia for acute pain states.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Constipation: reduced bowel movements.
  • Headache: mild throbbing pain.
  • Somnolence: increased sleepiness.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially in high‑dose or opioid‑naïve patients.
  • Seizures: risk heightened with high tramadol levels or interacting drugs.
  • Severe allergic reactions: anaphylaxis, skin rash, or angioedema.
  • Gastrointestinal bleeding or ulceration: due to NSAID component.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Stevens‑Johnson syndrome: rare severe skin reaction.

Precautions & Warnings

Before prescribing Lenizak, clinicians should consider several safety aspects.

  • Assess renal and hepatic function: adjust use in patients with impairment.
  • Review seizure history: tramadol may lower seizure threshold.
  • Check for hypersensitivity: avoid in individuals allergic to tramadol or dexketoprofen.
  • Monitor for serotonin syndrome: be cautious with serotonergic agents.
  • Evaluate bleeding risk: NSAID component can increase bleeding tendency.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lenizak may interact with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis and serotonin syndrome.
  • SSRIs, SNRIs, or other serotonergic drugs: increased serotonin syndrome potential.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.
  • CYP2D6 inhibitors (e.g., quinidine, fluoxetine): may raise tramadol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Other NSAIDs: heightened gastrointestinal bleeding risk.
  • Anticoagulants (e.g., warfarin): may potentiate anticoagulant effect.
  • Antihypertensives: NSAID component can attenuate blood‑pressure control.

Frequently Asked Questions

Lenizak is a prescription oral tablet that combines tramadol hydrochloride and dexketoprofen to treat moderate to severe acute pain, post‑operative pain, and musculoskeletal pain in adult patients.

Tramadol provides central analgesia by weakly stimulating µ‑opioid receptors and inhibiting norepinephrine and serotonin reuptake, while dexketoprofen reduces peripheral inflammation by blocking COX‑1 and COX‑2 enzymes, together delivering synergistic pain relief.

The appropriate dose of Lenizak is determined by the prescribing clinician based on the patient’s pain severity, medical history, and concomitant therapies. Patients should follow the exact instructions provided on the prescription label.

Safety data for Lenizak in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing women.

To request Lenizak, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑component opioids or NSAIDs, Lenizak offers a dual mechanism that can achieve effective analgesia at lower individual drug doses, potentially reducing the incidence of dose‑related side effects while still addressing both central and peripheral pain pathways.

Lenizak tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep out of reach of children.

Lenizak is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the specific instructions given by their healthcare provider.

Serious risks include respiratory depression, seizures, severe allergic reactions such as anaphylaxis, and gastrointestinal bleeding. Patients should seek immediate medical attention if they experience difficulty breathing, convulsions, rash, or vomiting blood.

Lenizak should be avoided in individuals with known hypersensitivity to tramadol, dexketoprofen, or any component of the formulation, as well as in patients taking MAO inhibitors, uncontrolled epilepsy, or severe hepatic or renal impairment without specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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