Product image of Lenospread (Piroxicam) supplied by GNH India

Lenospread

Active Ingredient:
Piroxicam
Origin:
EU

Lenospread (Piroxicam)

Piroxicam, the active ingredient in Lenospread, is a nonsteroidal anti-inflammatory drug presented as a topical formulation for cutaneous use. It works by inhibiting cyclooxygenase enzymes, thereby decreasing prostaglandin synthesis, which helps to alleviate pain, swelling, and redness in affected tissues such as joints, muscles, and inflamed skin lesions.

GNH India supplies Lenospread as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with robust quality assurance and regulatory compliance.

Manufacturer / TM Owner

I.B.N. Savio S.R.L.

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Indications & Clinical Uses

  • Piroxicam topical is used to manage pain and inflammation in conditions affecting the musculoskeletal system and skin.
  • Musculoskeletal pain: provides localized relief of pain and swelling in muscles, tendons, and ligaments.
  • Osteoarthritis: reduces joint pain and stiffness in affected joints.
  • Rheumatoid arthritis flare‑ups: alleviates localized joint inflammation.
  • Actinic keratosis: helps treat precancerous skin lesions by reducing inflammation.

How It Works

  • Piroxicam exerts its anti‑inflammatory and analgesic effects by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition reduces the conversion of arachidonic acid to prostaglandins, key mediators of inflammation, pain, and fever, thereby decreasing local inflammatory responses at the site of application.

Side Effects

Topical application of piroxicam may be associated with local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: redness, itching, or burning at the application site.
  • Dryness: localized skin dryness.
  • Erythema: mild redness of the treated area.
  • Pruritus: itching sensation.
  • Contact dermatitis: mild allergic skin reaction.

Serious or Rare Side Effects

  • Severe allergic reaction: angioedema or anaphylaxis.
  • Skin ulceration: necrotic lesions at the application site.
  • Systemic NSAID toxicity: rare gastrointestinal bleeding or renal impairment when large surface areas are treated.

Precautions & Warnings

  • When using Lenospread, consider the following safety measures to minimize risks.
  • Avoid application on broken or infected skin: may increase systemic absorption.
  • Limit use to prescribed area: excessive surface area can raise systemic exposure.
  • Do not use with other topical NSAIDs: risk of additive irritation.
  • Monitor for signs of hypersensitivity: discontinue if severe rash develops.
  • Store below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Piroxicam can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Systemic anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., furosemide): possible reduction in renal function.
  • ACE inhibitors or ARBs: may impair renal function when combined.
  • Lithium: piroxicam may increase lithium levels.

Frequently Asked Questions

Lenospread is a topical formulation containing piroxicam, an NSAID that is used to relieve pain and reduce inflammation in musculoskeletal conditions such as joint or muscle aches, as well as in certain inflammatory skin disorders.

Piroxicam inhibits both COX‑1 and COX‑2 enzymes, which blocks the synthesis of prostaglandins—key chemicals that promote inflammation, pain, and fever. By lowering prostaglandin levels at the site of application, the product reduces local swelling and discomfort.

The appropriate amount and frequency of Lenospread are determined by the prescribing healthcare professional based on the specific condition, severity, and patient factors. Patients should follow the prescriber’s instructions and not exceed the recommended application area.

Safety of topical piroxicam in pregnancy or lactation has not been fully established. Healthcare providers usually weigh potential benefits against risks, and it may be avoided unless clearly needed. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their clinician.

To request Lenospread, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenospread contains piroxicam, which offers a longer duration of action compared with some other topical NSAIDs such as diclofenac. Its non‑selective COX inhibition provides broad anti‑inflammatory coverage, but the choice of product depends on the specific indication, tolerability, and clinician preference.

Lenospread should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not freeze or expose the product to extreme temperatures.

The product is applied topically to the affected skin area, usually in a thin layer, and gently massaged until absorbed. The exact frequency and duration are set by the prescriber, and the treated skin should be clean and dry before application.

Serious risks, though rare, include severe allergic reactions such as angioedema or anaphylaxis, skin ulceration at the application site, and systemic NSAID toxicity that could lead to gastrointestinal bleeding or renal impairment, especially when large skin areas are treated.

Lenospread should be avoided in individuals with known hypersensitivity to piroxicam or any component of the formulation, in patients with active gastrointestinal ulcers, severe renal or hepatic impairment, and on broken or infected skin unless directed by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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