Product image of Lenotac (Piroxicam) supplied by GNH India

Lenotac

Active Ingredient:
Piroxicam
Origin:
EU

Lenotac (Piroxicam)

Piroxicam, the active ingredient in Lenotac, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for skin application. It belongs to the topical anti‑inflammatory/analgesic therapeutic class and is marketed in the European Union. It is used to relieve pain and inflammation associated with musculoskeletal conditions and certain inflammatory skin disorders in adults.

GNH India supplies Lenotac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is intended for professional healthcare use.

Manufacturer / TM Owner

I.B.N. Savio S.R.L.

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Indications & Clinical Uses

Piroxicam, a topical NSAID, is employed to manage inflammatory and painful conditions of the musculoskeletal and skin systems.

  • Osteoarthritis: reduces joint pain and swelling in affected joints.
  • Rheumatoid arthritis: alleviates joint inflammation and stiffness.
  • Sprains and strains: provides local pain relief and diminishes swelling.
  • Inflammatory skin conditions: decreases redness, edema and discomfort when NSAID therapy is indicated.

How It Works

  • Piroxicam inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes in peripheral tissues, blocking the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes the inflammatory cascade, leading to decreased pain, edema and erythema at the site of application.

Side Effects

Topical piroxicam can cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation or burning sensation at the application site.
  • Pruritus (itching).
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Mild rash.
  • Localized swelling.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Extensive skin ulceration or necrosis.
  • Systemic NSAID toxicity (e.g., renal impairment).
  • Hepatic dysfunction.
  • Cardiovascular events such as hypertension exacerbation.

Precautions & Warnings

Before using Lenotac, consider the following safety measures.

  • Assess patient history: verify no known hypersensitivity to piroxicam or other NSAIDs.
  • Avoid use on infected, open, or severely damaged skin.
  • Apply the lowest effective amount for the shortest duration needed.
  • Monitor for gastrointestinal symptoms, especially with extensive use.
  • Do not combine with systemic NSAIDs without medical supervision.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Piroxicam may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Concurrent systemic NSAIDs: increased risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin): heightened bleeding tendency.
  • Systemic corticosteroids: additive risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: monitor electrolyte balance and renal parameters.
  • Lithium: potential increase in serum lithium levels.

Frequently Asked Questions

Lenotac is a topical formulation containing piroxicam, an NSAID. It is indicated for the local relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, sprains, strains and certain inflammatory skin conditions where topical NSAID therapy is appropriate.

Piroxicam blocks the activity of both COX‑1 and COX‑2 enzymes, which are required for prostaglandin production. By reducing prostaglandin levels in the treated tissue, it diminishes the inflammatory response, leading to less pain, swelling and redness at the site of application.

The amount of Lenotac to apply and the frequency of application are set by the prescribing healthcare professional based on the severity of the condition, the size of the treatment area and individual patient factors. No standard dosing regimen is provided here.

Safety data for topical piroxicam in pregnancy and lactation are limited. Healthcare providers usually weigh potential benefits against possible risks before prescribing. Patients who are pregnant, planning pregnancy or breastfeeding should discuss use with their physician.

To request Lenotac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenotac contains piroxicam, which has a relatively long half‑life among topical NSAIDs, allowing sustained prostaglandin inhibition. Compared with agents such as diclofenac or ibuprofen gels, piroxicam may offer prolonged anti‑inflammatory effects, but individual response and tolerability can vary, so choice should be guided by clinical judgment.

Lenotac should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, heat and direct sunlight. Do not freeze the product, and keep it out of reach of children.

The prescribed amount of Lenotac is spread thinly over the clean, dry skin of the affected area and gently massaged until absorbed. It should not be applied to broken, infected or excessively hairy skin unless directed by a clinician. Hands should be washed after application.

Serious adverse events, although rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, extensive skin ulceration, systemic NSAID toxicity affecting kidney or liver function, and significant bleeding when combined with anticoagulants.

Lenotac should be avoided in individuals with known hypersensitivity to piroxicam or any NSAID, in patients with active skin infections or open wounds at the intended site, and in those taking systemic NSAIDs, anticoagulants or corticosteroids without medical supervision. Pregnant or breastfeeding women should consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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