Product image of Lentocilin S 2400 (Benzathine Benzylpenicillin) supplied by GNH India

Lentocilin S 2400

Active Ingredient:
Benzathine Benzylpenicillin
Origin:
EU

Lentocilin S 2400 (Benzathine Benzylpenicillin)

Benzathine benzylpenicillin, the active ingredient in Lentocilin S 2400, is a penicillin (beta‑lactam antibiotic) presented as an injectable solution for intramuscular use. It treats streptococcal infections, syphilis, rheumatic fever prophylaxis and other bacterial infections susceptible to penicillin in appropriate patients.

GNH India supplies Lentocilin S 2400 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Atral, S.A.

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Indications & Clinical Uses

Lentocilin S 2400 is a penicillin antibiotic used to treat bacterial infections that are sensitive to beta‑lactam agents.

  • Streptococcal infections: provides rapid bactericidal therapy to resolve throat, skin and invasive streptococcal disease.
  • Syphilis: eradicates Treponema pallidum, achieving cure in early and late stages when administered appropriately.
  • Rheumatic fever prophylaxis: prevents recurrence of rheumatic fever by maintaining adequate serum penicillin levels.
  • Other susceptible bacterial infections: treats infections caused by penicillin‑sensitive organisms such as certain staphylococci and pneumococci.

How It Works

  • Benzathine benzylpenicillin is a long‑acting ester of penicillin G that releases the active drug slowly after intramuscular injection. The released penicillin G binds to penicillin‑binding proteins on bacterial cell walls, inhibiting the transpeptidation step of peptidoglycan synthesis, which leads to weakened cell walls and ultimately bacterial lysis.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Erythema: localized redness around the injection area.
  • Fever: low‑grade temperature elevation.
  • Nausea: transient upset stomach.
  • Diarrhea: mild gastrointestinal upset.
  • Headache: occasional tension‑type headache.

Serious or Rare Side Effects

  • Anaphylaxis: severe, potentially life‑threatening allergic reaction.
  • Serum sickness: immune complex‑mediated fever, rash and arthralgia.
  • Stevens‑Johnson syndrome: severe mucocutaneous blistering.
  • Clostridioides difficile‑associated diarrhea: severe colitis after disruption of gut flora.
  • Hemolytic anemia: immune‑mediated destruction of red blood cells.
  • Severe allergic reactions: including angioedema and bronchospasm.

Precautions & Warnings

Before using Lentocilin S 2400, consider the following safety measures.

  • Allergy assessment: confirm no history of severe penicillin allergy.
  • Renal impairment: adjust use in patients with reduced kidney function.
  • Hepatic disease: monitor liver function in patients with liver disorders.
  • Pregnancy and lactation: safety category unknown; weigh benefits against potential risks.
  • Concomitant medications: review for possible interactions that may affect efficacy or safety.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Benzathine benzylpenicillin may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Methotrexate: increased toxicity risk.
  • Live vaccines: reduced vaccine efficacy and possible infection.
  • Oral contraceptives: decreased hormonal effectiveness.

Moderate Interactions (Monitor Closely)

  • Aminoglycosides: possible antagonistic effect reducing bacterial killing.
  • Tetracyclines: may diminish penicillin activity.
  • Warfarin: potential alteration of INR, requiring closer coagulation monitoring.

Frequently Asked Questions

Lentocilin S 2400 contains benzathine benzylpenicillin, a long‑acting penicillin used to treat streptococcal infections, syphilis, rheumatic fever prophylaxis and other bacterial infections that are susceptible to penicillin, as determined by a qualified prescriber.

The drug slowly releases penicillin G after intramuscular injection. Penicillin G binds to bacterial penicillin‑binding proteins, blocking the final step of cell‑wall peptidoglycan synthesis, which weakens the wall and causes bacterial lysis and death.

The specific dose and dosing interval are set by the treating physician based on the infection type, severity, patient age, weight, renal function and local treatment guidelines. No standard regimen is provided here.

The pregnancy safety category for benzathine benzylpenicillin is not definitively established. Prescribers should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Breastfeeding mothers should consult a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Lentocilin S 2400 provides a long‑acting intramuscular depot of penicillin G, allowing less frequent dosing compared with short‑acting penicillins such as benzylpenicillin sodium. This can improve compliance for prophylaxis but may have a higher risk of injection‑site reactions.

Store the product at 2‑8 °C, protected from light. Do not freeze or shake the vial. Keep it in the original packaging until use to maintain stability and potency.

The medication is supplied as an injectable solution for intramuscular injection. A qualified healthcare professional administers the dose into a large muscle (typically gluteal or deltoid) using aseptic technique.

Serious risks include anaphylactic shock, serum sickness, severe skin reactions such as Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and hemolytic anemia. Immediate medical attention is required if any of these occur.

Patients with a known severe allergy to any penicillin or beta‑lactam antibiotic should avoid this product. Caution is also advised for individuals with severe renal or hepatic impairment, and for those with a history of severe hypersensitivity reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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