Product image of Lentogest (Hydroxyprogesterone Caproate) supplied by GNH India

Lentogest

Active Ingredient:
Hydroxyprogesterone Caproate
Origin:
EU

Lentogest (Hydroxyprogesterone Caproate)

Hydroxyprogesterone caproate, the active ingredient in Lentogest, is a progestogen presented as an injectable solution for intramuscular use. It is employed to lower the risk of preterm birth in pregnant women identified as being at increased risk. It is authorized in the European Union for this indication and is supplied as a sterile, preservative‑free solution.

GNH India supplies Lentogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Hydroxyprogesterone caproate is a progestogen used in the management of pregnancy‑related uterine activity.

  • Prevention of preterm birth: reduces the incidence of early delivery in pregnant women at risk.
  • History of spontaneous preterm delivery: lowers recurrence risk in subsequent pregnancies.
  • Short cervical length or other high‑risk obstetric factors: supports uterine quiescence and may decrease preterm labor incidence.

How It Works

  • Hydroxyprogesterone caproate binds to progesterone receptors in uterine tissue, producing a progestogenic effect that diminishes myometrial contractility, modulates inflammatory pathways, and promotes cervical stability, thereby helping to maintain pregnancy and reduce the likelihood of preterm labor.

Side Effects

Adverse reactions reported with intramuscular hydroxyprogesterone caproate include the following.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the administration site.
  • Local erythema or swelling: transient redness or puffiness.
  • Headache: occasional mild headache.
  • Nausea: occasional mild nausea.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or anaphylaxis in susceptible individuals.
  • Thromboembolic events: rare cases of deep vein thrombosis.
  • Hepatotoxicity: abnormal liver function tests reported rarely.

Precautions & Warnings

When using Lentogest, consider the following precautions.

  • Pregnancy: use only when the expected benefit justifies potential risk.
  • Breastfeeding: safety not established; weigh maternal benefit against infant exposure.
  • Allergy: avoid if hypersensitivity to hydroxyprogesterone caproate or formulation excipients is known.
  • Liver disease: monitor hepatic function as metabolism may be impaired.
  • Concomitant hormonal therapy: assess for additive progestogenic effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hydroxyprogesterone caproate may interact with other medicines as follows.

Major Interactions (Avoid)

  • Concurrent progestogenic agents: may increase overall progestogenic activity.
  • Estrogen‑containing contraceptives: potential additive hormonal effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma concentrations.
  • CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effectiveness.
  • Anticoagulants (e.g., warfarin): monitor coagulation parameters for altered bleeding risk.

Frequently Asked Questions

Lentogest contains hydroxyprogesterone caproate and is used to reduce the risk of preterm birth in pregnant women who are identified as being at increased risk, such as those with a prior preterm delivery or other high‑risk obstetric factors.

Hydroxyprogesterone caproate binds to progesterone receptors in the uterus, providing a progestogenic effect that lessens uterine contractility, modulates inflammatory pathways, and helps maintain cervical stability, thereby supporting the continuation of pregnancy.

The specific dose and dosing schedule of Lentogest are determined by the prescribing clinician based on the patient’s clinical condition and risk profile. The prescriber will set the appropriate regimen.

Lentogest is intended for use during pregnancy to lower preterm birth risk, but its safety in breastfeeding has not been established. Clinicians should evaluate the benefit‑risk balance for each individual.

To order Lentogest, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Lentogest’s active ingredient, hydroxyprogesterone caproate, is a long‑acting progestogen that offers a different mechanism from agents such as progesterone gel or vaginal suppositories. It provides systemic exposure via intramuscular injection, which can be advantageous for patients who prefer less frequent dosing.

Lentogest should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. The product should be handled in accordance with aseptic techniques to maintain sterility.

Lentogest is supplied as a sterile injectable solution that is administered by a healthcare professional via intramuscular injection, typically into the gluteal or deltoid muscle, following the dosing schedule prescribed by the clinician.

Serious risks, though rare, include allergic reactions such as anaphylaxis, thromboembolic events like deep‑vein thrombosis, and potential liver function abnormalities. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Lentogest should be avoided in individuals with known hypersensitivity to hydroxyprogesterone caproate or any formulation excipients, and it should be used with caution in patients with severe liver disease or those taking other progestogenic or estrogenic medications without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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