Product image of Lenvatinib Biogaran (Lenvatinib) supplied by GNH India

Lenvatinib Biogaran

Active Ingredient:
Lenvatinib
Origin:
EU

Lenvatinib Biogaran (Lenvatinib)

Lenvatinib, the active ingredient in Lenvatinib Biogaran, is a tyrosine kinase inhibitor presented as an oral dosage form for oral use. It targets several advanced solid tumours by inhibiting angiogenic and proliferative signalling pathways in adult patients with documented efficacy in clinical trials.

GNH India supplies Lenvatinib Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for cross‑border distribution. Customers benefit from reliable lead times and comprehensive technical documentation.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

Lenvatinib is indicated for solid tumours that depend on angiogenesis and growth‑factor signalling.

  • Differentiated thyroid cancer: improves progression‑free survival in patients with radioactive‑iodine‑refractory disease.
  • Hepatocellular carcinoma: used in combination with atezolizumab for advanced disease.
  • Renal cell carcinoma: provides an oral option for metastatic clear‑cell RCC after prior therapy.
  • Endometrial cancer: approved for patients with advanced or recurrent disease not amenable to surgery.

How It Works

  • Lenvatinib blocks multiple receptor tyrosine kinases, including VEGFR 1‑3, FGFR 1‑4, PDGFRα, RET and KIT. By inhibiting these receptors it reduces tumor‑driven angiogenesis, disrupts proliferative signaling, and impairs stromal support, leading to decreased tumor growth and vascular supply. The inhibition is dose‑dependent and results in downstream suppression of MAPK and PI3K‑AKT pathways, contributing to anti‑tumor activity across a range of malignancies.

Side Effects

Lenvatinib may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Hypertension
  • Diarrhea
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Hepatic failure
  • Severe hemorrhage
  • Fistula formation

Precautions & Warnings

When prescribing Lenvatinib, clinicians should observe several safety measures to minimise risk.

  • Monitor blood pressure: check weekly and manage hypertension promptly.
  • Assess liver function: perform baseline and periodic LFTs.
  • Evaluate thyroid function: monitor TSH levels due to possible hypothyroidism.
  • Watch for bleeding: avoid concomitant use with anticoagulants unless necessary.
  • Avoid in patients with uncontrolled cardiovascular disease: consider alternative therapy.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture.

Avoid Interactions

Lenvatinib interacts with several medicines that can alter its exposure or increase toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Anticoagulants and high‑dose aspirin: increase risk of severe bleeding.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: dose adjustments may be required due to blood‑pressure changes.
  • Diuretics: monitor electrolytes and renal function.
  • Other tyrosine‑kinase inhibitors: combined use may enhance toxicity.

Frequently Asked Questions

Lenvatinib Biogaran is a prescription medicine used to treat several advanced solid tumours, including differentiated thyroid cancer, hepatocellular carcinoma, renal cell carcinoma and endometrial cancer. It works by blocking key signalling pathways that drive tumour growth and blood‑vessel formation.

Lenvatinib inhibits multiple receptor tyrosine kinases such as VEGFR 1‑3, FGFR 1‑4, PDGFRα, RET and KIT. Blocking these receptors reduces angiogenesis, limits tumour cell proliferation and disrupts the supportive tumour micro‑environment, thereby slowing disease progression.

The dose of Lenvatinib is individualized by the treating physician based on the specific cancer type, patient characteristics and any concomitant therapies. Only a qualified prescriber can determine the appropriate strength, schedule and duration of treatment.

Safety data for Lenvatinib during pregnancy or lactation are limited, and the drug may cause fetal harm. It is generally advised to avoid use in pregnant or nursing women unless the potential benefit justifies the potential risk, and to discuss alternatives with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lenvatinib Biogaran. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenvatinib is a multi‑targeted tyrosine kinase inhibitor, offering oral administration and a broad receptor profile. Compared with agents such as sorafenib, it provides additional inhibition of FGFR and RET, which can translate into different efficacy and safety profiles. Choice of therapy depends on tumour type, prior treatments and individual patient factors.

Lenvatinib should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Lenvatinib is taken orally, usually once daily, with a glass of water. It can be swallowed with or without food, but patients should follow the specific instructions provided by their prescriber and avoid crushing or chewing the tablets.

The most serious adverse events include severe hypertension, hepatic failure, major bleeding, and the development of fistulas. Patients should be monitored regularly for blood‑pressure spikes, liver‑function abnormalities, signs of bleeding and any unusual wound healing problems.

Lenvatinib is contraindicated in patients with known hypersensitivity to the drug or any of its excipients, and it should be avoided in individuals with uncontrolled cardiovascular disease, severe hepatic impairment, or active bleeding disorders unless the prescriber determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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