Product image of Lenvima (Lenvatinib) supplied by GNH India

Lenvima

Active Ingredient:
Lenvatinib
Origin:
EU

Lenvima (Lenvatinib)

Lenvatinib, the active ingredient in Lenvima, is a tyrosine kinase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of certain advanced cancers, including radioactive iodine‑refractory differentiated thyroid cancer, renal cell carcinoma, hepatocellular carcinoma, and endometrial carcinoma, in adult patients.

GNH India supplies Lenvima as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across regions. We adhere to stringent quality standards and provide reliable logistics support for timely delivery.

Manufacturer / TM Owner

Eisai Gmbh

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Indications & Clinical Uses

  • Lenvima (lenvatinib) is indicated for several solid tumours that depend on angiogenesis and growth‑factor signalling.
  • Radioactive iodine‑refractory differentiated thyroid cancer: improves progression‑free survival in adult patients.
  • Renal cell carcinoma: delays disease progression in patients with advanced disease.
  • Hepatocellular carcinoma: extends overall survival in unresectable cases.
  • Endometrial carcinoma: provides clinical benefit in patients with advanced disease.

How It Works

  • Lenvatinib blocks multiple receptor tyrosine kinases that drive tumour angiogenesis and cell proliferation, including VEGFR1‑3, FGFR1‑4, PDGFRα, RET and KIT. By inhibiting these pathways, the drug reduces new blood‑vessel formation and interferes with signalling that supports tumour growth, leading to slowed disease progression.

Side Effects

Common Side Effects

  • Fatigue or weakness
  • Hypertension
  • Diarrhoea
  • Nausea or vomiting
  • Decreased appetite
  • Hand‑foot skin reaction

Serious or Rare Side Effects

  • Hepatotoxicity (liver injury)
  • Cardiac failure or reduced ejection fraction
  • Severe bleeding or thromboembolic events
  • Gastrointestinal perforation
  • Severe hypertension crisis

Precautions & Warnings

Patients should be monitored regularly for blood pressure, liver function, and cardiac status during therapy.

  • Blood pressure monitoring: check at baseline and periodically throughout treatment.
  • Liver function tests: assess before starting and during therapy.
  • Cardiac evaluation: perform echocardiogram if risk factors exist.
  • Pregnancy and lactation: avoid use; discuss contraception with prescriber.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Lenvima may interact with several concomitant medicines that affect its metabolism or increase toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise lenvatinib exposure.
  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): increase bleeding risk.
  • High‑dose aspirin or NSAIDs: augment gastrointestinal bleeding.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower drug levels.
  • Diuretics: can exacerbate hypertension.
  • Hormonal contraceptives: reduced efficacy may occur; advise alternative methods.

Frequently Asked Questions

Lenvima (lenvatinib) is prescribed for adult patients with radioactive iodine‑refractory differentiated thyroid cancer, advanced renal cell carcinoma, unresectable hepatocellular carcinoma, and advanced endometrial carcinoma. It is used when these cancers require targeted inhibition of angiogenesis and tumour‑cell signalling.

Lenvatinib inhibits multiple receptor tyrosine kinases such as VEGFR1‑3, FGFR1‑4, PDGFRα, RET and KIT. Blocking these receptors reduces new blood‑vessel formation and interferes with signalling pathways that promote tumour cell proliferation, thereby slowing disease progression.

The appropriate dose of Lenvima is determined individually by the prescribing oncologist based on the specific cancer type, patient weight, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Lenvima is classified as contraindicated in pregnancy because it may cause fetal harm. Women of child‑bearing potential should use effective contraception during treatment and for a period after the last dose. Breastfeeding is not recommended, as the drug may be excreted in milk.

To order Lenvima, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lenvima uniquely targets a broad spectrum of kinases, including VEGFR, FGFR, PDGFRα, RET and KIT, offering a wider anti‑angiogenic profile than some single‑target TKIs. This multi‑target approach can be advantageous in tumours that rely on several growth‑factor pathways, but the safety profile and drug‑interaction potential also differ and must be considered.

Lenvima tablets should be stored at ambient temperature, below 25 °C, in the original blister pack. Protect the medication from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Lenvima is taken orally as a tablet, usually once daily on an empty stomach (at least one hour before or two hours after a meal). The tablet should be swallowed whole with water and not crushed, chewed, or split unless specifically instructed by a healthcare professional.

Serious risks include severe hypertension, liver toxicity, cardiac dysfunction (including reduced ejection fraction), gastrointestinal perforation, and life‑threatening bleeding or thromboembolic events. Patients should be monitored closely for these events, and any concerning symptoms should be reported to a clinician immediately.

Lenvima is contraindicated in patients with known hypersensitivity to lenvatinib or any of its excipients. It should be avoided in individuals who are pregnant, breastfeeding, or have uncontrolled hypertension, severe hepatic impairment, or significant cardiac disease without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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