Product image of Lenzetto (Estradiol Hemihydrate) supplied by GNH India

Lenzetto

Active Ingredient:
Estradiol Hemihydrate
Origin:
EU

Lenzetto (Estradiol Hemihydrate)

Estradiol Hemihydrate, the active ingredient in Lenzetto, is an estrogen presented as a transdermal patch for transdermal use. It treats moderate to severe menopausal vasomotor symptoms, helps prevent osteoporosis in postmenopausal women, and addresses hypoestrogenism caused by ovarian failure or hypogonadism.
GNH India supplies Lenzetto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Lenzetto, an estrogen therapy, is indicated for several menopause‑related and hypoestrogenic conditions.

  • Menopausal vasomotor symptoms: relief of moderate to severe hot flashes and night sweats.
  • Postmenopausal osteoporosis: prevention of bone loss and reduction of fracture risk.
  • Hypoestrogenism due to ovarian failure: restoration of estrogen levels in women with ovarian insufficiency.
  • Hypogonadism: treatment of estrogen deficiency in women with hypogonadal states.

How It Works

  • Estradiol hemihydrate in Lenzetto binds to estrogen receptors ERα and ERβ in target tissues, initiating receptor dimerization and recruitment of co‑activators. This modulates transcription of estrogen‑responsive genes, restoring estrogenic activity that alleviates vasomotor symptoms, supports bone remodeling, and normalizes reproductive‑system function.

Side Effects

Lenzetto may cause adverse reactions typical of systemic estrogen exposure.

Common Side Effects

  • Skin irritation at patch site: redness, itching, or rash.
  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: swelling or discomfort.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Stroke: cerebrovascular accident.
  • Endometrial hyperplasia or carcinoma: abnormal uterine bleeding.

Precautions & Warnings

Before prescribing Lenzetto, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Cardiovascular risk: assess history of thromboembolic events before use.
  • Breast cancer: avoid in women with active or past estrogen‑dependent breast cancer.
  • Liver disease: use with caution in severe hepatic impairment.
  • Pregnancy and lactation: contraindicated; avoid in pregnant or breastfeeding women.
  • Store at room temperature below 25°C: keep in original pouch, protect from moisture and light.

Avoid Interactions

Estradiol can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid)

  • Oral anticoagulants (warfarin): may increase clotting risk.
  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole): can raise estradiol plasma levels.
  • Hormonal contraceptives: additive estrogen effect may increase thrombotic risk.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: estrogen may reduce blood‑pressure control.
  • Thyroid hormones: may alter thyroid‑binding globulin and hormone levels.
  • Antidepressants (SSRIs): may affect hot‑flash control and estrogen metabolism.

Frequently Asked Questions

Lenzetto is prescribed to relieve moderate to severe vasomotor symptoms of menopause, to help prevent osteoporosis in postmenopausal women, and to treat hypoestrogenism caused by ovarian failure or other forms of hypogonadism.

Estradiol hemihydrate binds to estrogen receptors α and β, activating gene transcription that restores estrogen activity in target tissues. This action reduces hot flashes, supports bone mineral density, and normalizes estrogen‑dependent physiological processes.

The prescribed dose of Lenzetto is determined by the treating physician based on the individual’s clinical condition. Typically, the patch is applied to the skin and replaced according to the schedule set by the prescriber.

Lenzetto is contraindicated in pregnancy and breastfeeding because systemic estrogen can affect fetal development and milk production. Women who are pregnant, planning pregnancy, or nursing should not use this product.

To order Lenzetto, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lenzetto delivers estradiol through the skin, bypassing first‑pass hepatic metabolism, which can result in more stable serum levels and potentially fewer liver‑related side effects compared with oral tablets. The transdermal route may also have a lower impact on clotting factors, but individual risk profiles should guide therapy choice.

Store Lenzetto at room temperature below 25 °C, in its original pouch, protected from moisture and direct light. Do not expose the patch to excessive heat or humidity, and keep it out of reach of children.

Lenzetto is applied to clean, dry, hair‑free skin on the lower abdomen, buttock or upper arm. The patch should be pressed firmly for several seconds, and the site should be rotated with each new application according to the prescriber’s schedule.

Serious risks include venous thromboembolism, stroke, and endometrial hyperplasia or carcinoma. Patients should be educated to seek immediate medical attention for symptoms such as unexplained leg pain, sudden shortness of breath, severe headache, or abnormal uterine bleeding.

Lenzetto should not be used by women with a history of estrogen‑dependent breast cancer, active thromboembolic disease, uncontrolled hypertension, severe liver disease, or by anyone who is pregnant or breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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