Product image of Lepicortinolo (Prednisolone) supplied by GNH India

Lepicortinolo

Active Ingredient:
Prednisolone
Origin:
EU

Lepicortinolo (Prednisolone)

Prednisolone, the active ingredient in Lepicortinolo, is a glucocorticoid presented as an oral tablet for systemic use. It reduces inflammation and modulates immune responses, making it suitable for treating a range of inflammatory, allergic and autoimmune conditions in adult patients. It is used for both short‑term and chronic management and is administered under medical supervision to achieve optimal therapeutic outcomes while minimizing systemic exposure.

GNH India supplies Lepicortinolo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established quality‑assurance processes and regulatory compliance across EU and other markets.

Manufacturer / TM Owner

Angelini Pharma Portugal Unipessoal Lda.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Prednisolone acts on inflammatory and immune pathways, providing therapeutic benefit across several disease categories.

  • Rheumatoid arthritis: reduces joint inflammation and pain, improving mobility.
  • Asthma exacerbations: diminishes airway inflammation, aiding symptom control.
  • Systemic lupus erythematosus: suppresses autoimmune activity, decreasing disease flares.
  • Severe allergic reactions: mitigates hypersensitivity responses, relieving edema and urticaria.

How It Works

  • Prednisolone penetrates cell membranes and binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex interacts with glucocorticoid response elements on DNA, up‑regulating anti‑inflammatory proteins such as annexin‑1 and down‑regulating pro‑inflammatory cytokines, chemokines, and adhesion molecules, thereby suppressing the immune response and reducing inflammation. It also decreases capillary permeability and stabilizes lysosomal membranes, contributing to its overall anti‑edematous effect.

Side Effects

Prednisolone may cause a range of adverse reactions, varying from mild, frequently observed effects to rare but potentially life‑threatening events.

Common Side Effects

  • Increased appetite: may lead to weight gain.
  • Mood changes: irritability or euphoria.
  • Insomnia: difficulty sleeping.
  • Gastrointestinal discomfort: nausea or dyspepsia.
  • Fluid retention: mild edema.

Serious or Rare Side Effects

  • Severe infection: heightened susceptibility.
  • Osteoporosis: bone density loss.
  • Adrenal suppression: cortisol axis inhibition.

Precautions & Warnings

When prescribing Prednisolone, clinicians should consider several precautionary measures to ensure patient safety.

  • Monitor blood glucose: check for hyperglycemia, especially in diabetics.
  • Assess infection risk: avoid use in active systemic infections.
  • Evaluate bone health: consider calcium/vitamin D supplementation.
  • Review psychiatric history: watch for mood swings or psychosis.
  • Taper gradually: prevent adrenal insufficiency upon discontinuation.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Prednisolone can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: reduce prednisolone levels (e.g., rifampicin, phenytoin).
  • Anticoagulants (warfarin): increase bleeding risk.
  • NSAIDs: elevate gastrointestinal ulcer risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypokalemia.
  • Antidiabetic agents: may require dose adjustment due to hyperglycemia.
  • Vaccines: live vaccine efficacy may be diminished.

Frequently Asked Questions

Lepicortinolo, containing prednisolone, is prescribed for a variety of inflammatory and immune‑mediated disorders such as rheumatoid arthritis, asthma exacerbations, systemic lupus erythematosus, severe allergic reactions, and other conditions where suppression of inflammation or immune activity is required.

Prednisolone binds to intracellular glucocorticoid receptors, forming a complex that moves into the cell nucleus. There it modulates gene expression by increasing anti‑inflammatory proteins and decreasing pro‑inflammatory cytokines, chemokines, and adhesion molecules, which collectively reduces inflammation and dampens immune responses.

The appropriate dose of Lepicortinolo is individualized by the prescribing clinician based on the specific condition, severity, patient weight, comorbidities, and response to therapy. No fixed dosing regimen is provided here; the prescriber will set the exact dosage and schedule.

The pregnancy category for prednisolone is listed as unknown, and safety data are limited. Use during pregnancy or lactation should only occur when the potential benefit justifies any potential risk, and it must be discussed with a qualified healthcare professional.

To request Lepicortinolo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lepicortinolo delivers prednisolone, a medium‑potency glucocorticoid. Compared with higher‑potency agents such as dexamethasone, prednisolone generally has a shorter half‑life and may require more frequent dosing, but it offers a well‑characterized safety profile and is often preferred for moderate inflammatory conditions.

Lepicortinolo tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister or container to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lepicortinolo is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Administration timing (e.g., with food) may be advised by the prescriber to reduce gastrointestinal irritation.

Serious risks include severe infections due to immune suppression, adrenal insufficiency on abrupt discontinuation, osteoporosis with long‑term use, and gastrointestinal bleeding or ulceration, especially when combined with NSAIDs. Patients should be monitored closely for signs of these complications.

Lepicortinolo is contraindicated in patients with known hypersensitivity to prednisolone or any excipients, those with systemic fungal infections, and individuals receiving live vaccines without appropriate medical guidance. Caution is also advised for patients with uncontrolled diabetes, severe hypertension, or active peptic ulcer disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.