Product image of Lercanidipin Accord (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipin Accord

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipin Accord (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipin Accord, is a calcium channel blocker presented as an oral tablet for oral administration. It works by relaxing vascular smooth muscle, thereby reducing peripheral vascular resistance and lowering elevated blood pressure in adult patients diagnosed with hypertension.

GNH India supplies Lercanidipin Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring product quality through stringent manufacturing standards and regulatory adherence. The company provides reliable logistics and documentation support for global distribution.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Lercanidipine is used as an antihypertensive agent acting on the calcium‑channel pathway to control high blood pressure.

  • Hypertension: reduces systolic and diastolic blood pressure, helping patients reach target levels in primary hypertension.
  • Isolated systolic hypertension: improves arterial compliance and lowers pressure in elderly patients with elevated systolic readings.

How It Works

  • Lercanidipine hydrochloride selectively blocks L-type calcium channels in vascular smooth muscle cells. By inhibiting calcium influx, it prevents contraction of arterial smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: especially upon standing.
  • Tachycardia: increased heart rate.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic injury: signs of liver dysfunction.
  • Allergic reaction: rash, itching, or swelling.
  • Arrhythmia: abnormal heart rhythm.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Blood pressure monitoring: regularly assess to ensure therapeutic response.
  • Cardiac assessment: evaluate for existing heart disease before use.
  • Concomitant antihypertensives: adjust doses to avoid excessive hypotension.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Other calcium channel blockers: additive vasodilatory effect can cause hypotension.
  • Grapefruit juice: can elevate drug concentration.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance blood pressure‑lowering effect.

  • Beta‑blockers: combined effect may require dose adjustment.
  • ACE inhibitors or ARBs: monitor for excessive blood pressure reduction.

Frequently Asked Questions

Lercanidipin Accord contains lercanidipine hydrochloride, which is prescribed to lower elevated blood pressure in adults diagnosed with hypertension. It belongs to the calcium channel blocker class and helps achieve target blood pressure levels by relaxing blood vessels.

Lercanidipine selectively blocks L-type calcium channels in the smooth muscle of arterial walls. This inhibition reduces calcium entry, preventing muscle contraction, leading to vasodilation, decreased peripheral resistance, and a subsequent reduction in systemic blood pressure.

The appropriate dose of Lercanidipin Accord is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercanidipine is a long‑acting dihydropyridine calcium channel blocker, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. Compared with beta‑blockers or ACE inhibitors, it primarily induces vasodilation without affecting heart rate or renin‑angiotensin activity, making it a useful option for patients who need vascular relaxation.

Lercanidipin Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Lercanidipin Accord is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water and do not crush or chew it unless specifically instructed.

Serious adverse events, although rare, can include severe hypotension, myocardial infarction, hepatic injury, allergic reactions, and arrhythmias. Patients should seek immediate medical attention if they experience symptoms such as fainting, chest pain, jaundice, rash, or irregular heartbeat.

Lercanidipin Accord is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation, and in those with severe aortic stenosis or unstable angina. Caution is also advised for individuals with significant liver impairment or who are taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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