Product image of Lercanidipina Alter (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Alter

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Alter (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipina Alter, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower elevated blood pressure in adult patients with hypertension.

GNH India supplies Lercanidipina Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured batches that meet EU regulatory standards for distribution across global markets. The company provides comprehensive logistics support, regulatory documentation, and timely delivery to facilitate import and local compliance.

Manufacturer / TM Owner

Alter S.A.

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Indications & Clinical Uses

Lercanidipine is used to treat hypertension, a condition characterized by chronically elevated arterial pressure.

  • Essential hypertension: reduces both systolic and diastolic blood pressure to target levels.
  • Isolated systolic hypertension: provides arterial vasodilation that lowers high systolic readings.
  • Secondary hypertension (e.g., renovascular): used as adjunct therapy to help control blood pressure.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle cells, inhibiting calcium influx that is necessary for muscle contraction. This results in relaxation of arterial smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and consequently lowered blood pressure. The drug’s high lipophilicity allows prolonged action and a once‑daily dosing regimen.

Side Effects

Lercanidipine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate headache occurring after initiation.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: sensation of light‑headedness, especially when standing.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or airway requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure leading to fainting or shock.
  • Hepatic dysfunction: abnormal liver enzyme elevations or hepatitis.

Precautions & Warnings

When prescribing lercanidipine, clinicians should consider several precautionary measures to ensure safe use.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Concomitant antihypertensives: evaluate risk of additive blood pressure lowering.
  • Sudden discontinuation: avoid abrupt stopping to prevent rebound hypertension.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels and risk of hypotension.
  • Grapefruit juice: can markedly raise lercanidipine concentrations.
  • Other potent vasodilators (e.g., nitroglycerin): may cause additive hypotensive effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce drug exposure and effectiveness.
  • Diuretics: may enhance blood pressure lowering, requiring dose adjustment.
  • Beta‑blockers: combined use may increase risk of bradycardia or excessive blood pressure reduction.

Frequently Asked Questions

Lercanidipina Alter contains lercanidipine, a calcium‑channel‑blocking agent indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure in adult patients, reducing the risk of cardiovascular complications associated with high blood pressure.

Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium‑induced contraction. This causes arterial relaxation, decreases peripheral vascular resistance, and ultimately lowers systemic blood pressure. Its high lipophilicity provides a prolonged duration of action suitable for once‑daily dosing.

The appropriate dose of Lercanidipina Alter is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. Dosage adjustments may be required for special populations, and patients should follow the prescriber’s instructions precisely.

Safety of lercanidipine in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the possible risk to the fetus or infant. Healthcare providers must evaluate individual circumstances before prescribing to pregnant or nursing women.

To request Lercanidipina Alter, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class of calcium‑channel blockers and lower blood pressure by vasodilation. Lercanidipine is more lipophilic, which may result in a longer half‑life and once‑daily dosing, while amlodipine has a well‑established safety profile. Choice of agent depends on clinical judgment, patient tolerance, and drug‑interaction considerations.

Lercanidipina Alter should be stored at room temperature, below 25 °C, in the original packaging to protect it from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Lercanidipina Alter is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise instructed.

Serious adverse events, although rare, include angioedema, severe hypotension, and hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling of the face or throat, a sudden drop in blood pressure with fainting, or signs of liver injury such as jaundice or dark urine.

Lercanidipina Alter is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, unstable angina, or those taking interacting medications that could precipitate dangerous hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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