Product image of Lercanidipina Aurobindo (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Aurobindo

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Aurobindo (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipina Aurobindo, is a calcium channel blocker presented as an oral tablet formulation for systemic administration. It works by relaxing vascular smooth muscle, thereby reducing peripheral resistance and helping to control hypertension in adult patients.

GNH India supplies Lercanidipina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under appropriate regulatory standards. The company ensures consistent quality, traceability and on‑time delivery across global markets. Its supply chain adheres to WHO GMP guidelines and supports local regulatory submissions.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Lercanidipine acts on the cardiovascular system to lower elevated arterial pressure in several hypertension subtypes.

  • Essential hypertension: reduces systolic and diastolic blood pressure in adults.
  • Isolated systolic hypertension: improves pulse pressure control.
  • Secondary hypertension: assists in managing blood pressure when caused by other medical conditions.

How It Works

  • Lercanidipine selectively blocks L-type calcium channels in vascular smooth muscle cells, preventing calcium influx that is necessary for muscle contraction. This inhibition leads to relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate pain often occurring shortly after dosing.
  • Flushing: sensation of warmth and redness, especially on the face.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness or light‑headedness, particularly when standing quickly.
  • Fatigue: feeling unusually tired without exertion.
  • Tachycardia: increased heart rate in some patients.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or throat that may compromise breathing.
  • Severe hypotension: marked drop in blood pressure causing fainting or shock.
  • Myocardial infarction: rare occurrence of heart attack, especially in patients with pre‑existing coronary disease.
  • Hepatic injury: abnormal liver function tests or hepatitis.
  • Severe allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for specific concerns.

  • Blood pressure monitoring: check regularly to ensure therapeutic response and avoid excessive lowering.
  • Discontinuation: avoid abrupt cessation; taper if clinically indicated.
  • Hepatic impairment: use with caution and consider dose adjustment.
  • Pregnancy and lactation: consult a physician; benefits must outweigh potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations and risk of hypotension.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy by lowering drug levels.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive blood‑pressure‑lowering effect, may cause bradycardia.

  • Diuretics: enhanced antihypertensive response, monitor electrolytes.
  • Grapefruit juice: can increase lercanidipine exposure, advise patients to limit intake.

Frequently Asked Questions

Lercanidipina Aurobindo contains lercanidipine, a calcium‑channel‑blocking agent indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure in adult patients, reducing the risk of cardiovascular complications associated with high blood pressure.

Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth‑muscle cells. By blocking calcium entry, it prevents muscle contraction, leading to vasodilation of peripheral arteries. This vasodilation decreases systemic vascular resistance, which in turn lowers arterial blood pressure.

The exact dosage is determined by the prescribing clinician based on the patient’s clinical condition, age, and response to therapy. In practice, clinicians often start with a low daily dose and may adjust it as needed, but the final regimen must always be set by a qualified healthcare professional.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments with their healthcare provider.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. Compared with beta‑blockers, it primarily causes vasodilation rather than heart‑rate reduction, making it a useful alternative for patients who cannot tolerate beta‑blockers or ACE inhibitors.

Lercanidipina Aurobindo tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

The medication is taken orally, usually once daily. Patients should swallow the tablet whole with a full glass of water and may take it with or without food, as directed by their prescriber. Consistent timing each day helps maintain stable blood‑pressure control.

Serious adverse events, although rare, include angioedema, severe hypotension, myocardial infarction, and significant liver injury. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, chest pain, or signs of liver dysfunction such as jaundice.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, as well as in individuals with severe hypotension, cardiogenic shock, or unstable heart failure. Clinicians should also exercise caution in patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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