Product image of Lercanidipina Ciclum (Lercanidipine Hydrochloride Hemihydrate) supplied by GNH India

Lercanidipina Ciclum

Active Ingredient:
Lercanidipine Hydrochloride Hemihydrate
Origin:
EU

Lercanidipina Ciclum (Lercanidipine Hydrochloride Hemihydrate)

Lercanidipine, the active ingredient in Lercanidipina Ciclum, is a calcium channel blocker presented as an oral tablet for systemic use. It is indicated for the management of hypertension in adult patients, helping to lower elevated blood pressure. The drug acts by selectively inhibiting L‑type calcium channels in vascular smooth muscle, producing vasodilation and a reduction in peripheral vascular resistance.

GNH India supplies Lercanidipina Ciclum as a licensed, GDP‑compliant international pharmaceutical product, sourced from the European Union market, and distributes it to hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Lercanidipine is a calcium channel blocker used to treat conditions within the hypertension disease family.

  • Essential hypertension: lowers systolic and diastolic blood pressure.
  • Primary hypertension: improves overall blood pressure control.
  • High blood pressure: reduces cardiovascular risk associated with sustained elevation.

How It Works

  • Lercanidipine selectively antagonizes L‑type calcium channels on vascular smooth‑muscle cells, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or feet.
  • Dizziness: sensation of light‑headedness.
  • Tachycardia: increased heart rate.
  • Nausea: mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare cardiac event.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Allergic reactions: rash, pruritus, or urticaria.
  • Angioedema: swelling of face, lips, or throat.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Hepatic impairment: use with caution and consider dose adjustment.
  • Concomitant antihypertensives: assess for additive blood‑pressure‑lowering effects.
  • Pregnancy and lactation: safety data are limited; prescribe only if benefits outweigh risks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, requiring attention to avoid clinically significant effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations.
  • Grapefruit juice: can elevate drug levels and risk of hypotension.
  • Other potent vasodilators: may cause additive blood‑pressure reduction.
  • Aliskiren in diabetic patients: increased risk of renal impairment.
  • Simultaneous use with other calcium‑channel blockers: heightened cardiovascular effects.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can blunt antihypertensive response.
  • Diuretics: monitor electrolytes and blood pressure.
  • Beta‑blockers: observe for bradycardia.
  • Anticoagulants: watch for bleeding risk due to potential platelet effects.

Frequently Asked Questions

Lercanidipina Ciclum contains lercanidipine, a calcium‑channel‑blocking agent indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure in adult patients by relaxing arterial smooth muscle and reducing peripheral vascular resistance.

Lercanidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells, preventing calcium entry that is necessary for muscle contraction. This inhibition leads to vasodilation, decreased peripheral resistance, and a subsequent reduction in systemic blood pressure.

The appropriate dose of lercanidipine is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and any concomitant medications. Dosage adjustments are made according to therapeutic response and tolerability.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent vasodilation with a relatively long half‑life. Compared with ACE inhibitors or ARBs, it primarily reduces peripheral resistance without affecting the renin‑angiotensin system, and it may be combined with those agents for additive blood‑pressure control.

Store the tablets at room temperature, preferably below 25 °C, in the original packaging. Protect them from moisture, direct sunlight, and excessive heat to maintain product stability throughout its shelf life.

Lercanidipina Ciclum is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

Serious adverse events, although rare, include severe hypotension, myocardial infarction, hepatic dysfunction, allergic reactions such as angioedema, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, or swelling of the face or throat.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. Caution is advised for individuals with severe hepatic impairment, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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