Product image of Lercanidipina Falgi (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Falgi

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Falgi (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipina Falgi, is a calcium channel blocker presented as an oral dosage form for oral use. It is employed to lower elevated blood pressure in adults diagnosed with hypertension.

GNH India supplies Lercanidipina Falgi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gp – Genéricos Portugueses, Lda.

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Indications & Clinical Uses

Lercanidipine is used to manage conditions within the hypertension disease family by relaxing vascular smooth muscle and reducing systemic vascular resistance.

  • Essential hypertension: provides sustained reduction of systolic and diastolic blood pressure.
  • Isolated systolic hypertension: improves control of elevated systolic readings.
  • Secondary hypertension (e.g., renal‑related): assists in achieving target blood pressure when used as part of combination therapy.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells, inhibiting calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure without significant effect on cardiac contractility.

Side Effects

Adverse reactions may occur with any antihypertensive therapy and should be monitored.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness, especially after standing.
  • Tachycardia: increased heart rate.
  • Fatigue or general weakness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Severe allergic reactions: rash, itching, or anaphylaxis.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Hepatic impairment: use with caution; dose adjustment may be required.
  • Concomitant antihypertensives: assess for additive blood‑pressure lowering effects.
  • Renal function: monitor in patients with compromised kidney function.
  • Pregnancy and lactation: consult obstetric specialist before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine may interact with other medicines that affect its metabolism or blood‑pressure‑lowering action.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations and risk of hypotension.
  • Co‑administration with other potent antihypertensives (e.g., ACE inhibitors, beta‑blockers): can cause excessive blood‑pressure reduction.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of renal impairment.
  • Grapefruit juice: can elevate lercanidipine levels.
  • Diuretics: may enhance orthostatic hypotension.
  • Lipid‑lowering agents (e.g., statins): monitor for additive muscle toxicity.

Frequently Asked Questions

Lercanidipina Falgi contains lercanidipine, a calcium channel blocker indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure by relaxing arterial smooth muscle, thereby reducing the workload on the heart and decreasing the risk of cardiovascular complications associated with high blood pressure.

Lercanidipine selectively inhibits L‑type calcium channels on vascular smooth‑muscle cells. By blocking calcium entry, it prevents muscle contraction, leading to vasodilation of peripheral arteries. This vasodilation reduces systemic vascular resistance, which in turn lowers arterial blood pressure without significantly affecting heart rate or contractility.

The appropriate dose of Lercanidipina Falgi is determined by the prescribing healthcare professional based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives and risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a lower incidence of cough and may be better tolerated in patients who experience bradycardia. However, individual response varies, and combination therapy is often employed to achieve optimal blood‑pressure control.

Lercanidipina Falgi should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include angioedema, severe hypotension, myocardial infarction, and significant hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, chest pain, or unexplained liver‑related symptoms such as jaundice.

Lercanidipina Falgi is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, unstable angina, or those who have experienced a recent myocardial infarction unless specifically directed by a cardiologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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