Product image of Lercanidipina Mylan Italia (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Mylan Italia

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Mylan Italia (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipina Mylan Italia, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by lowering elevated blood pressure and reducing cardiovascular risk.

GNH India supplies Lercanidipina Mylan Italia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan S.P.A.

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Indications & Clinical Uses

  • Lercanidipine is a dihydropyridine calcium channel blocker indicated for the management of hypertension.
  • Hypertension: Lowers elevated blood pressure, helping to prevent stroke, myocardial infarction and other cardiovascular complications.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx. This results in relaxation of arterial smooth muscle, vasodilation, and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure without significant effect on cardiac contractility.

Side Effects

Lercanidipine may cause a range of adverse reactions. Most are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness or light‑headedness, especially after standing.
  • Tachycardia: increased heart rate.
  • Fatigue or general weakness.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of the face, lips, tongue or throat.
  • Myocardial infarction: rare cases of heart attack.
  • Elevated liver enzymes: indicating possible hepatic involvement.
  • Severe allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess cardiac status: avoid use in patients with unstable angina or recent myocardial infarction.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: tapering can prevent rebound hypertension.
  • Pregnancy and lactation: consult a physician; limited safety data are available.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations and risk of hypotension.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive blood‑pressure‑lowering effect, may require dose adjustment.

  • Diuretics: can enhance orthostatic hypotension.
  • Simvastatin or other statins metabolised by CYP3A4: increased risk of myopathy; monitor lipid‑lowering therapy.

Frequently Asked Questions

Lercanidipina Mylan Italia contains lercanidipine, a calcium channel blocker prescribed to lower high blood pressure in adults. By reducing systemic vascular resistance, it helps control hypertension and lowers the risk of cardiovascular events such as stroke or heart attack.

Lercanidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells. This inhibition prevents calcium entry, causing the muscles to relax, which dilates arteries and reduces peripheral resistance. The resulting vasodilation lowers arterial pressure without markedly affecting heart rate.

The appropriate dose of lercanidipine is determined individually by a qualified prescriber based on the patient’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the exact dosing instructions provided by their healthcare professional.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class of calcium channel blockers and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may be associated with a lower incidence of peripheral edema, while amlodipine is more widely studied and available in many fixed‑dose combinations.

Lercanidipina Mylan Italia tablets should be stored at ambient temperature, below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and keep out of reach of children.

Lercanidipine is taken orally, usually once daily. It can be swallowed with or without food; however, consistent intake with respect to meals helps maintain stable plasma levels. Patients should not crush or chew the tablets.

Serious adverse events, though rare, include severe hypotension, angioedema, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, chest pain, or signs of liver dysfunction.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, in those with severe hypotension, cardiogenic shock, or unstable angina. Caution is also advised for patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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