Product image of Lercanidipina Ratiopharm (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Ratiopharm

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Ratiopharm (Lercanidipine Hydrochloride)

Lercanidipine hydrochloride, the active ingredient in Lercanidipina Ratiopharm, is a calcium channel blocker presented as a tablet for oral use. It works by relaxing vascular smooth muscle, thereby lowering blood pressure and is indicated for the management of hypertension in adult patients.

GNH India supplies Lercanidipina Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across global markets with adherence to stringent quality standards.

Manufacturer / TM Owner

Ratiopharm-Comercio E Industria De Produtos Farmaceuticos Lda

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Indications & Clinical Uses

  • Lercanidipine, a dihydropyridine calcium channel blocker, is employed in the therapeutic management of elevated blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Isolated systolic hypertension: lowers systolic pressure in patients with predominant systolic elevation.
  • Essential hypertension: provides long‑term control of primary high blood pressure.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx that is necessary for contraction. This antagonism induces dose‑dependent vasodilation of peripheral arteries, decreasing systemic vascular resistance and consequently lowering arterial blood pressure without significant effect on cardiac conduction.

Side Effects

Lercanidipine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Severe hypotension
  • Angioedema
  • Myocardial infarction
  • Hepatic dysfunction

Precautions & Warnings

  • When prescribing lercanidipine, clinicians should consider several safety measures.
  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use caution and consider dose adjustment in patients with liver dysfunction.
  • Concomitant antihypertensives: evaluate risk of additive blood pressure lowering.
  • Elderly patients: start at low dose and monitor for dizziness or falls.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lercanidipine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Grapefruit juice: can markedly raise drug concentration.
  • Other calcium channel blockers: additive vasodilatory effect leading to hypotension.
  • Anti‑arrhythmic agents (e.g., diltiazem): risk of severe bradycardia.
  • Concurrent use with other antihypertensives at high doses: risk of excessive blood pressure drop.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce effectiveness.
  • Diuretics: may enhance orthostatic hypotension.
  • Beta‑blockers: monitor for combined heart rate reduction.
  • NSAIDs: may blunt antihypertensive response.
  • Alcohol: can increase dizziness and hypotensive effect.

Frequently Asked Questions

Lercanidipina Ratiopharm contains lercanidipine hydrochloride, which is prescribed to lower elevated blood pressure in adults diagnosed with hypertension. By reducing systemic vascular resistance, it helps to control blood pressure and lower the risk of cardiovascular events associated with high blood pressure.

Lercanidipine selectively blocks L‑type calcium channels in the smooth muscle of blood vessels. This inhibition prevents calcium‑mediated contraction, leading to vasodilation of peripheral arteries, a decrease in systemic vascular resistance, and ultimately a reduction in arterial blood pressure.

The appropriate dose of lercanidipine is determined by the prescribing healthcare professional based on the individual’s blood pressure, response to therapy, and any co‑existing medical conditions. The prescriber will select the starting dose and may adjust it according to therapeutic goals and tolerability.

Safety of lercanidipine in pregnancy and lactation has not been fully established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To request Lercanidipina Ratiopharm, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. After verification, the team provides pricing, availability, shipping details (including any required temperature control) and assists with import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may provide smoother blood‑pressure control with a lower incidence of reflex tachycardia, whereas amlodipine is widely used and has an extensive safety record. Choice of therapy depends on patient‑specific factors and clinician preference.

Store Lercanidipina Ratiopharm at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight to maintain potency throughout the shelf‑life.

Lercanidipina Ratiopharm is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional and not alter the dose without medical advice.

Serious adverse events, although uncommon, include severe hypotension, angioedema, myocardial infarction, and hepatic dysfunction. Patients should seek immediate medical attention if they experience symptoms such as sudden dizziness, swelling of the face or throat, chest pain, or signs of liver injury.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. It should be used with caution in individuals with severe hepatic impairment, unstable angina, or a history of significant hypotension. A healthcare professional must evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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